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1)  lopinavir
洛匹那韦
1.
(2S,3S,5S)-2,5-Diamino-3-hydroxy-1,6-diphenylhexane, the key intermediate of lopinavir was synthesized from L-phenylalanine by N,O-benzylation, cyanidation, Grignard reaction and reduction to give (2S,3S,5S)-5-amino-2-dibenzylamino-1,6-diphenylhexan-3-ol, which was subjected to debenzylation with an overall yield of about 63%.
L-苯丙氨酸用氯苄进行N,O-苄基化、氰化、格氏反应、还原制得(2S,3S,5S)-5-氨基-2-二苄胺基-1,6-二苯基-3-己醇,再经钯炭催化脱苄制得抗病毒药洛匹那韦中间体(2S,3S,5S)-2,5-二氨基-3-羟基-1,6-二苯基己烷,总收率约为63%。
2)  Nelfinavir
奈非那韦
1.
Novel Synthesis and Spectral Characterization of Nelfinavir;
奈非那韦的新法合成及其光谱表征
2.
As the anti-HIV-1 agents call trigger mechanisms involved in chemoresistance,to test whether prolonged in vitro treatment of Jurkat cell s with nelfinavir alters sensitivity of lymphoma cells to antitumor agents used fo r AIDS-associated maliglancies.
目的 体外研究奈非那韦耐性细胞株对其它抗艾滋病药及抗癌药的反应及与细胞凋亡的关系。
3)  Amprenavir
安普那韦
1.
Synthesis and Analysis of HIV Protease Inhibitor Amprenavir;
抗HIV蛋白酶抑制剂安普那韦的合成
4)  saquinavir
沙奎那韦
1.
Determination of Saquinavir in Plasma by RP-HPLC;
反相高效液相色谱法测定血浆中沙奎那韦浓度
2.
Effect of ketoconazole on metabolism in vitro and pharmacokinetics of saquinavir;
酮康唑对沙奎那韦体外代谢和药物代谢动力学的影响
3.
Synthesis of saquinavir,an HIV protease inhibitor,was researched via convergence method.
采用平行-连续法合成了H IV蛋白酶抑制剂沙奎那韦。
5)  Zanamivir
扎那米韦
1.
Inhibition Effects of Zanamivir and Other Five Drugs on Neuramidinase in Influenza Virus;
扎那米韦等对流感病毒神经氨酸酶的抑制作用
2.
Zanamivir was synthesized with salic acid as starting material by enzymatic catalysis method.
以自制唾液酸为起始原料,对扎那米韦的合成工艺进行研究。
6)  ritonavir
利托那韦
1.
Pharmacokinetics Study of Ritonavir in Chinese Healthy Volunteers;
利托那韦在国人体内的药代动力学研究
2.
Synthetic Study of Intermediates for Anti-Aids Drug-Ritonavir;
抗艾滋病药物—利托那韦中间体的合成研究
3.
Stavudine and Ritonavir are effective therapeutic agents for the treatmentof AIDS.
司它夫定(Stavudine)和利托那韦(Ritonavir)是FDA正式批准的治疗艾滋病的高效抗逆转录病毒治疗(HAART)药物。
补充资料:洛匹那韦
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