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1)  low density lipoprotein receptor
低密度脂蛋白受体
1.
The Effects of Ramification of Curcumin Hydrolyzed on Proliferation of Vascular Smooth Muscle Cells and Expression of Low Density Lipoprotein Receptor;
姜黄素水解衍生物对血管平滑肌细胞增殖及低密度脂蛋白受体表达的影响
2.
Effect of Astragalus membranaceus and Radix Salviae miltiorrhizae on low density lipoprotein receptor in rabbits;
丹参黄芪配伍对家兔低密度脂蛋白受体的影响
3.
Analysis of low density lipoprotein receptor function and gene mutation in familial hypercholesterolemic patients;
家族性高胆固醇血症纯合子家系低密度脂蛋白受体功能检测及基因突变分析
2)  LDLR
低密度脂蛋白受体
1.
The LDLR and HMGR mRNA expression were also detected.
检测给药前后血清总胆固醇(TC)、总甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)含量,并计算动脉粥样硬化指数;检测给药后各组低密度脂蛋白受体(LDLR)和羟甲戊二酰辅酶A受体mRNA的表达量。
2.
, a traditional medicine of Zang nationality in China, on fat rats forced by high-fat diet and the effect of its chemical components on LDLR.
目的:探讨藏药烈洗对高脂饮食诱导的肥胖大鼠的治疗作用以及烈洗所含化学成分对低密度脂蛋白受体(LDLR)的影响。
3.
Method: On the basis of hyperlipidemia rat models, triglycerides(TG), total cholesterol (TC) in serum, activities of lipase (LA), lipoprotein lipase (LPL), hepatic lipase (HL) in liver, parts of hemogram and hepatic LDLR mRNA levels were investigated 21 days after the feeding of atherogenic diet.
目的 :探讨温胆汤对高脂血症大鼠低密度脂蛋白受体基因表达的影响。
3)  LDL receptor
低密度脂蛋白受体
1.
OBJECTIVE To establish a method for investigating the function of LDL receptor using the double labeled of ligand tagged with the colloid gold and the fluorescein in cell.
目的建立一种利用胶体金-荧光素双标记配体研究细胞低密度脂蛋白受体(LDLR)功能的方法。
2.
Objectives Cholesterol is derived from two pathways, one is the uptake of plasma via LDL receptor-mediated endocytosis, the other is from cellular synthesis.
过去的研究中,我们已经证实炎性因子可以通过干扰胆固醇介导的低密度脂蛋白受体(LDLr)反馈调节来促进外周细胞,如肾系膜细胞(HMCs)、血管平滑肌细胞(VSMC)的胆固醇摄入,以及抑制ATP结合盒转运体A1(ABCA1)基因的表达来减少胆固醇外流从而导致胆固醇在外周细胞异常积聚形成泡沫细胞。
3.
Sterol regulatory element binding proteins (SREBPs) cleavage-activating protein(SCAP),which is an important molecule in regulating the expression LDL receptor and 3-hydroxy-3-methylglutaryl-CoA(HMGCoA) reductase under inflammatory stress, plays vital functions for intracellular cholesterol homeostasis.
固醇调控元件结合蛋白(SREBPs)裂解激活蛋白(SCAP)是细胞内胆固醇敏感器,是调控低密度脂蛋白受体(LDL receptor)和3-羟甲基戊二酸单酰CoA还原酶(HMGCoA reductase)表达的上游重要分子,在维持细胞内胆固醇稳态平衡中起重要作用。
4)  LDL-R
低密度脂蛋白受体
1.
Objective:To explore the effect of FPS on low-density lipoprotein acceptor(LDL-R) mRNA in the liver tissues of hyperlipidemic rats.
目的:探讨褐藻糖胶(FPS)对高脂血症大鼠肝低密度脂蛋白受体(LDL-R)mRNA表达的影响。
2.
Objective: To investigate the anti-proliferation of three different structural curcumin pigmen monomers on the bovine VSMC stimulated by ox-LDL and the effect on the expression of LDL-R.
目的:研究3种不同结构的姜黄色素单体对牛主动脉平滑肌细胞(VSMC)增殖及牛VSMC低密度脂蛋白受体(LDL-R)表达的影响,解析构效关系。
3.
And to synthetically evaluate the hyperlipidemic effect of RLE To observe the effects of RLF on expression of low-density lipoprotein receptor(LDL-R)gene in hyperlipidemia mice.
并观察丝瓜络对高脂血症小鼠肝组织低密度脂蛋白受体(Low-density lipoprotein receptor,LDL-R)基因表达的影响,探讨从分子水平上丝瓜络降血脂的作用机制。
5)  low-density lipoprotein receptor
低密度脂蛋白受体
1.
We studied the effect of livial on the expression of estrogen receptor and low-density lipoprotein receptor mRNA in heart and liver with half quantity RT-PCR.
以去势雌兔作为对照,用高胆固醇饮食法复制动脉粥样硬化(AS)模型,研究了利维爱(Livial)在防治兔动脉粥样硬化过程中对雌激素受体和低密度脂蛋白受体mRNA表达的影响。
2.
In present study, atherosclerotic animal model were replicated with high cholesterol feedstuff , and the expressions of estrogen receptor α and low-density lipoprotein receptor mRNA in heart and liver were studied by half quantitive RT-PCR, the rabbits oophorectomized and fed with normal feedstuff were used as control.
采用βactin做内参照的半定量RTPCR方法,对2组去势雌兔心脏、肝脏组织内雌激素受体α和低密度脂蛋白受体mRNA的表达进行了研究。
6)  LOX-1
低密度脂蛋白受体-1
1.
Effects of candesartan on aorta oxidative stress-LOX-1 pathway in salt-loaded stroke-prone spontaneously hypertensive rats;
坎地沙坦对盐负荷高血压大鼠主动脉氧化应激-低密度脂蛋白受体-1通路的抑制
补充资料:低密度脂蛋白
分子式:
CAS号:

性质: 又称β-脂蛋白。血浆中脂蛋白系非均一的物质,用超速离心或电泳法对血浆脂蛋白进行类别分离。密度(g/cm3)<0.95为乳糜微粒(CM),0.95~1.006为极低密度脂蛋白(VLDL),1.006~1.063为低密度脂蛋白(LDL),1.063~1.21为高密度脂蛋白。分子量(2.2~3.5)×106,分子直径1.7~2.6μm,含甘油三酯、磷脂、胆固醇酯、脂肪酸、蛋白等,其主要功能拟为运输内源性胆固醇和胆固醇酯,调节周围组织胆固醇合成。在血管内皮细胞上有LDL和VLDL的受体,可接受循环血中的血脂而沉积于管壁上,证明LDL与动脉粥样硬化和冠状动脉粥样硬化有关。人体LDL的正常值范围:40岁以下,<500mg%,40岁以上,<610mg%。如果值增高可作为高脂蛋白血症(Ⅱ型)、冠心病、糖尿病、脂肪肝、肾病综合征的参数。

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