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1)  resolution kinetics
拆分动力学
1.
The factors influencing the enantioselectivity of enzyme catalyzed asymmetric transformations in organic phase, and the enzymatic resolution kinetics are discussed.
总结了有机溶剂中的酶催化研究进展,讨论了影响有机溶剂中酶促不对称转化过程对映体选择性的因素和拆分动力学
2)  kinetic resolution
动力学拆分
1.
Bulk liquid membrane (BLM) containing D-(+)-dibenzoyltartaric acid (D-(+)-DBTA) as chiral carrier was used for the resolution of racemic clenbuterol, the optimal chiral extraction conditions and the kinetic resolution model were established.
以D-(+)-二苯甲酰酒石酸(D-(+)-DBTA)为流动载体,研究了克伦特罗(clenbuterol,Cle)对映体的厚体液膜法拆分,建立了手性拆分条件和动力学拆分模型。
2.
While a great progress was achieved in the domain of enzymatic kinetic resolution during the past years, non-enzymatic kinetic resolution is becoming another current hot area, which mainly refers to enanti-oselective acylation, oxidation, reduction, ring-opening, ring-closing, substitution and addition, etc.
动力学拆分是合成光学纯化合物的重要方法之一。
3.
Kinetic resolution is the most widely used method in the production of enantiomer pure ketoprofen.
介绍了生产酮洛芬单一对映体常用的动力学拆分法及该工艺过程存在的不足。
3)  dynamic kinetic resolution
动态动力学拆分
1.
The dynamic kinetic resolution (DKR) of racemic compounds provides one of the most convenient and efficient routes to a wide range of enantiomerically enriched molecules.
动态动力学拆分是合成具有光学活性化合物最方便和最有效的方法之一。
2.
Dynamic kinetic resolution (DKR) has extended the scope of methodology for preparation of enantiopure compounds.
动态动力学拆分扩展了制备单一手性化合物的工艺方法。
3.
The methods of kinetic resolution,dynamic kinetic resolution and enantioconvergence resolution were compared with each other.
系统地综述了酶法手性拆分技术的最新研究和应用进展,对动力学拆分、动态动力学拆分和对映体收敛转化3种方法进行了比较,并介绍了酶,尤其是脂肪酶在非水介质中催化酯和氨基化合物的立体选择性水解、转酯化和酰胺化的研究进展及其在技术上遇到的问题和解决方法。
4)  hydrolytic kinetic resolution
水解动力学拆分
1.
L-(–)-Carnitine was synthesized from epichlorohydrin by selective hydrolytic kinetic resolution with chiral salen-CoIII complexes to give (S)-(+)-epichlorohydrin, which was subjected to quaternarization, cyanidation, hydrolysis and then ionic exchange with an overall yield of about 70% based on (S)-(+)-epichlorohydrin.
以自制手性salen-CoⅢ为催化剂,水解动力学拆分外消旋环氧氯丙烷,得到高光学纯度的(S)-(+)-环氧氯丙烷,再经季胺化、氰化、水解及离子交换制得L-(–)-肉碱,总收率70%[以(S)-(+)-环氧氯丙烷计]。
2.
The hydrolytic kinetic resolution (HKR) of racemic terminal epoxides catalyzed by chiral (salen)Co could afford optically active terminal epoxides.
用手性 (Salen)Co催化剂催化的外消旋末端环氧化合物的水解动力学拆分反应所得的手性末端环氧化合物和各种取代的胺和烷氧负离子反应 ,可得到光学纯的 β 胺基醇和 β 烷氧基醇类化合物 ,这两类化合物是重要的生物活性分子 。
3.
Chiral Salen reacted with cobalt acetate and oxidized to give the Salen-Co(III) complex (S,S)-2, which catalyzes the hydrolytic kinetic resolution of racemic epoxides to afford chiral epoxides and diols in good yield with the e.
将 (S ,S) 1,2 二苯基乙二胺 (DPEDA)与 2 羟基 5 甲基 3 叔丁基苯甲醛缩合 ,得到手性Salen ,再与Co络合 ,氧化后得到Salen Co(III)手性催化剂 ,用于催化外消旋环氧化合物的水解动力学拆分 ,得到了光学活性的环氧化合物和二醇 ,产率较高 ,对映体过量 2 0 。
5)  parallel kinetic resolution
平行动力学拆分
6)  enzymatic kinetic resolution
酶动力学拆分
1.
The difference between a continuous stirred tank reactor (CSTR) and a batch reactor was analyzed for the enzymatic kinetic resolution of enantiomers.
描述了在批式反应器和连续流搅拌反应器 ( CSTR)中酶动力学拆分对映异构体的不同之处。
补充资料:动力学拆分
分子式:
CAS号:

性质:外消旋体与一手性试剂(包括酶)反应时,它们的过渡态是非对映的,具有不同的活化能。如果反应是不可逆地进行,则具有低活化能的反应是主反应,成为主要产物。当用不足量的手性试剂与外消旋体反应,则其中一个对映体优先与手性试剂反应生成产物,而余下的是富集的另一对映体,这就是动力学拆分。如下式所示。(±)-A+(+)-B(不足量)→(-)-A·(+)-B+(+)-A

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