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1)  HIF-1α
缺氧诱导因子-1α
1.
Role of Hypoxia-inducible Factor-1α(HIF-1α) and Angiogenic Factors in Peritoneal Metastases and Prognosis of Advanced Serous Ovarian Cancer;
缺氧诱导因子-1α及血管生长因子与晚期卵巢浆液性癌腹膜播散和预后相关性分析
2.
THE EFFECT OF HIF-1α INHIBITOR ON THE INJURY INDUCED BY FOCAL CEREBRAL ISCHEMIA AND REPERFUSION IN RATS;
缺氧诱导因子-1α抑制剂对大鼠局部脑缺血再灌注损伤的影响
3.
Detection of COX-2,HIF-1α and microvessel density in cutaneous carcinoma tissue;
皮肤癌组织中环氧合酶-2和缺氧诱导因子-1α的表达及微血管密度测定
2)  Hypoxia-inducible factor-1α
缺氧诱导因子-1α
1.
Expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in the retina of diabetic rats;
糖尿病大鼠视网膜中缺氧诱导因子-1α和血管内皮生长因子表达的研究
2.
Effects of Chinese herbs for replenishing qi and resolving stagnation on hypoxia-inducible factor-1α and vascular endothelial growth factor in granulation tissue of skin ulcers in rats with diabetes;
益气化瘀中药对糖尿病皮肤溃疡大鼠缺氧诱导因子-1α和血管内皮细胞生长因子的影响
3.
Expression of hypoxia-inducible factor-1α in endometriosis;
缺氧诱导因子-1α在子宫内膜异位症的表达及意义
3)  Hypoxia inducible factor-1α
缺氧诱导因子-1α
1.
Expression and correlation between erythropoietin mRNA and hypoxia inducible factor-1α mRNA in rats with brain ischemic tolerance;
脑缺血耐受大鼠促红细胞生成素和缺氧诱导因子-1α的表达及其相关性
2.
Construction and expression of adeno-associated virus vector harboring human hypoxia inducible factor-1αgene;
重组人缺氧诱导因子-1α腺相关病毒载体的构建及表达
3.
Relationship between nuclear factor-κB and hypoxia inducible factor-1α expression in nasal polyps;
核因子-κB与鼻息肉组织中缺氧诱导因子-1α表达的相关性研究
4)  Hypoxia inducible factor 1α
缺氧诱导因子-1α
1.
Effect of taurine on hypoxia inducible factor 1α expression of retina in rats exposed to hypoxia;
牛磺酸对缺氧大鼠视网膜缺氧诱导因子-1α表达的影响
2.
Objective To investigate the influence of hypoxia on the expressions of hypoxia inducible factor 1α and vascular endothelial growth factor,the angiogenic response and its mechanism.
目的:探讨缺氧对人胶质瘤细胞株U251缺氧诱导因子-1α和血管内皮生长因子表达及血管生成反应的影响及机制。
5)  hypoxia-inducible factor-1 alpha
缺氧诱导因子-1α
1.
Expression of Hypoxia-inducible Factor-1 Alpha in Gastric Adenocarcinoma and Its Relationship with Cell Proliferation and Angiogenesis;
胃腺癌组织中缺氧诱导因子-1α的表达及其与细胞增殖和血管形成的关系
2.
The overexpression and clinical significance of hypoxia-inducible factor-1 alpha and carbonic anhydrase Ⅸ in renal cell carcinoma;
目的探讨缺氧诱导因子-1α(HIF-1α)与碳酸酐酶9(CAⅨ)在肾细胞癌中的表达及相互关系。
6)  HIF-1α
缺氧诱导因子1α
1.
Objective To investigate the effect of trichostatin A(TSA) on the expression of HIF-1α and VEGF in lung adenocarcinoma cell line A549 under hypoxic condition.
目的探讨组蛋白去乙酰化酶1抑制剂曲古抑菌素A(trichostain A,TSA)对低氧条件下人肺腺癌细胞株A549缺氧诱导因子1α(hypoxia induced factor 1α,HIF-1α)和血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。
2.
HIF-1α,a crucial transcriptional control gene in signaling cell to adapt to anaerobic microenvironment,can activate the expression of many anaerobic-responding genes which includes the expression of Glut1 gene,in order to supply energy for tumor under hypoxia.
缺氧诱导因子1α(HIF-1α)是介导细胞对缺氧微环境进行适应性反应的关键性转录调控基因,能激活许多缺氧反应性基因的表达,其中包括促进肿瘤细胞Glut基因的表达,以满足在乏氧状态下,肿瘤生长的能量需求。
3.
Hypoxia-inducible factor-1α(HIF-1α) is a nuclear transcription factor which play activity in a state of hypoxia.
缺氧诱导因子1α(HIF-1α)是一个在缺氧状态下发挥活性的核转录因子,在胰腺癌组织及细胞中高表达,促进胰腺癌生长和血管生成,缺氧状态下,间质细胞和胰腺癌细胞之间的相互作用增加。
补充资料:α,α,α,α',α',α'-六氯对二甲苯
分子式:C8H4Cl6
分子量:312.84
CAS号:68-36-0

性质:白色针状或粉末状结晶。熔点108-110℃。溶于二甲苯、石油醚、乙醇、植物油,不溶于水。无味,有特殊臭味,遇光、碱会缓慢分解而呈酸性。

制备方法:以混二甲苯为原料,先用98%硫酸磺化,使间二甲苯生成间二甲苯磺酸盐。从磺化反应物中分离出含邻、对二甲苯的油层,水洗、干燥,减压蒸馏出邻、对二甲苯。间二甲苯磺酸盐经水解可得副产品间二甲苯。由邻、对二甲苯经氯化即得1,4-双(三氯甲基)苯:在反应锅中投入邻、对二甲苯,再加入过氧化苯甲酰和三乙醇胺。加热到70℃后,在光照射下导入氯气,于70-80℃反应6h,再升温至100-120℃继续反应,至反应液相对密度达到1.560-1.580(65℃),即为反应终点,停止通氯,减压脱除余氯。降温至5℃,过滤,洗涤得粗品,重结晶,活性炭脱色得成品。

用途:抗血吸虫病药物。对肝吸虫病、阿米巴原虫病、疟疾以及肠道线虫有一定疗效。但对神经系统的不良反应较多见,且延迟反应持续较久。

说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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