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1)  TNF-α
肿瘤坏死因子-
1.
OBJECTIVE To study the expression of the level of tumor necrosis factor alpha(TNF-α) and total IgE in Mycoplasma pneumoniae(MP) infection and bronchial asthma,and to analyze its relation with disease severity.
目的测定哮喘合并支原体感染患儿血清肿瘤坏死因子-α(TNF-α)与总IgE的水平,探讨其水平与疾病严重程度的关系。
2.
Objective:To observe and explore the influence of Ganoderma lucidum spores on the TNF-α and ET-1 content in the hippocampus of rat with epilepsy caused by Pentetrazole(PTZ).
目的:观察和探讨灵芝孢子粉对戊四氮(PTZ)致痫大鼠海马区肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)含量变化的影响。
3.
By using ELISA method,it was discovered in this paper the density of Tumor necrosis factor(TNF-α) in plasma and uteru mucus,before and after the treatment with Gongdekang suspension compoundes(NGDK) on metritis of dairy cow.
应用ELISA方法,研究了患子宫内膜炎奶牛用药前后血液及子宫粘液肿瘤坏死因子-α(TNF-α)的含量变化。
2)  tumor necrosis factor-α
肿瘤坏死因子-
1.
[Objective] To investigate the effects of insulin like growth factor 1(IGF-1) on apoptosis of cardiomyocytes induced by tumor necrosis factor-α(TNF-α) and its possible relationship with PI3K/Akt.
目的观察胰岛素样生长因子-1(IGF-1)对肿瘤坏死因子-α(TNF-α)处理的大鼠心肌细胞存活率的影响,并探讨其与PI3K/Akt通路的关系。
2.
Objective To study the relationship between free fatty acids,tumor necrosis factor-α and type 2 diabetic patients with macrovascular complications.
目的:探讨游离脂肪酸、肿瘤坏死因子-α与糖尿病大血管病变的关系。
3)  tumor necrosis factor-α
肿瘤坏死因子-α
1.
Expressions of vascular endothelial growth factor,tumor necrosis factor-α,CD1a and γδTCR~+ T in pleural effusion and peripheral blood and their diagnostic value analysis for tuberculosis and lung cancer;
血管内皮生长因子、肿瘤坏死因子-α、CD1a、γδTCR~+ T在胸腔积液和外周血中表达及其对肺结核和肺癌的诊断价值
2.
Effect of berberine hydrochloride on the expression of interleukin-1β and tumor necrosis factor-α in periodontal tissues in rats;
盐酸小檗碱对大鼠牙周组织中白细胞介素-1β和肿瘤坏死因子-α表达的影响
3.
Effect of Gymnadenia conopsea alcohol extract on pulmonary fibrosis of rats exposed to silica and the expression of tumor necrosis factor-α;
手掌参醇提取物处理染矽尘大鼠肺纤维化及肿瘤坏死因子-α表达的变化
4)  Tumor necrosis factor
肿瘤坏死因子
1.
Influence of ulinastain on tumor necrosis factor and interleukin-6 in patients after cardiopulmonary resuscitation;
乌司他汀对心肺复苏术后肿瘤坏死因子及白细胞介素-6变化影响的研究
2.
Relationship between tumor necrosis factor as well as laminin and Hepatic Diseases;
肿瘤坏死因子及层粘连蛋白与肝病的关系
3.
Level change of plasma tumor necrosis factor-α, nitric oxide and endotoxin in hepatorenal syndrome patients;
肝肾综合征患者血浆肿瘤坏死因子-α、一氧化氮及内毒素水平变化研究
5)  Tumor necrosis factor α
肿瘤坏死因子α
1.
Dynamical detection of tumor necrosis factor α mRNA expression in rat spinal cord of neuropathic pain using FQ-RT-PCR;
荧光定量PCR动态检测神经病理性疼痛大鼠脊髓肿瘤坏死因子α表达变化
2.
Alteration of serum tumor necrosis factor α concentration in different kinds of diabetic mice;
不同类型的糖尿病模型小鼠血清肿瘤坏死因子α水平的变化
3.
Effects of Centalla asiatica combining emodin on complement C3 in glomerular mesangial cells stimulated by Tumor Necrosis Factor α;
积雪草苷合大黄素对肿瘤坏死因子α诱导的肾系膜细胞C3表达的影响
6)  tumor necrosis factor-α(TNF-α)
肿瘤坏死因子-α
1.
Objective: To investigate the effect of Ghrelin on plasminogen activator inhibitor-1(PAI-1) mRNA expression in HepG2 cells induced by tumor necrosis factor-α(TNF-α) and the effect of nuclear factorκB(NF-κB).
目的:探讨Ghrelin对肿瘤坏死因子-α(TNF-α)诱导的HepG2细胞纤溶酶原激活物抑制剂-1(PAI-1)mRNA表达的影响及核因子-κB(NF-κB)在其中的作用。
2.
Objective To investigate significance of serum tumor necrosis factor-α(TNF-α) detection for diagnosis of intrahepatic cholestasis of pregnancy(ICP).
目的探讨肿瘤坏死因子-α在妊娠肝内胆汁淤积症发病中的作用。
3.
Objective:To study the pathology of liver injury in rats with obstructive jaundice and the relationship between Hepatic injury and Intercellular Adhesion Molecule-1(ICAM-1),Tumor Necrosis factor-α(TNF-α),Interleukin-1(IL-1).
目的:初步探讨大鼠梗阻性黄疸模型(obstructive jaundice,OJ)时肝脏损伤的病理变化及细胞间黏附分子-1(ICAM-1)、肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)与肝损伤的关系。
补充资料:肿瘤坏死因子
分子式:
CAS号:

性质:又称恶液质素(cachectin),淋巴毒素(lymphotoxin;LT)。注射卡介苗短小棒状杆菌和酵母多糖等制剂,再以内毒素攻击在小鼠、大鼠和兔等多种动物的血清中出现的一种能引起肿瘤出血性坏死的活性成分。含有唾液酸和半乳糖胺的一种糖蛋白,分子量约150 000。根据其产生来源和结构不同,可分为TNF-α和TNF-β两类,前者有单核-巨噬细胞产生,后者有活化T细胞产生,现已有基因重组技术制备。两类TNF的基本生物活性相似,除具有杀伤肿瘤细胞外,还有免疫调节,参与发热和炎症的发生。大剂量TNF-α可引起恶液质,医疗上可单独或白细胞介素2联合用于治疗肿瘤。

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