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1)  PAI-1
血清纤溶酶原激活物抑制物
1.
Experimental Study of Yiqi Yangyin Huoxue Recipe's Effect on Serum PAI-1 Level in IR Rat;
益气养阴活血方对胰岛素抵抗大鼠血清纤溶酶原激活物抑制物的影响
2)  plasminogen activator inhibitor-1
纤溶酶原激活物抑制物
1.
Objective:To analyze the plasma levels of tissue plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) in patients with coronary heart disease(CHD) and to assess its clinical implications.
方法:回顾性分析本院222例冠心病患者血浆组织型纤溶酶原激活物(t-PA)及纤溶酶原激活物抑制物-1(PAI-1)水平。
2.
ObjectiveTo evaluate the plasminogen activator system (plasminogen activator inhibitor-1 and tissue plasminogen activator) in women with PCOS and compared in groups .
目的:探讨纤溶酶原激活物抑制物-1(PAI-1)和组织型纤溶酶原激活物(t-PA)的高低与多囊卵巢综合征(polycystic ovary syndrome, PCOS)患者病变发展之间的关系以探寻一较好的监测指标。
3.
Objective To investigate the role of rosiglitazone in improving blood lipids and proteinuria in rats with Type 2 diabete,and the effect of rosiglitazone on expressions of plasminogen activator inhibitor-1 in kidney of streptozotocin-diabetic rats.
目的研究罗格列酮对2型糖尿病大鼠血糖血脂的影响及肾皮质纤溶酶原激活物抑制物1(PAI-1)表达的作用。
3)  plasminogen activator inhibitor
纤溶酶原激活物抑制物
1.
Objective To observe the influence of Shenluotong on the protein expression of plasminogen activator inhibitor 1(PAI-1) in kidney remaining tissue in rats with kidney failure induced by 5/6 of nephrectomy.
目的观察肾络通对5/6肾切除肾衰竭大鼠残余肾组织纤溶酶原激活物抑制物-1(PAI-1)蛋白表达的影响。
2.
The activities of tissue plasminogen activator(tPA),plasminogen activator inhibitor(PAI) and plasminogen(PLG) in plasma were determined by chromogenic substrate assay,and thrombi weight was measured.
先给大鼠喂药后以FeCl3诱导左侧颈总动脉血栓形成,以发色底物法测定血浆组织型纤溶酶原激活物(tPA)、纤溶酶原激活物抑制物(PAI)和纤溶酶原(PLG)活性,并测定血栓质量。
3.
Objective To investigate the changes of serum plasminogen activator inhibitor(PAI),D-dimer and thrombomodulin(TM),and the relationship between these changes and phlegm syndrome or blood-stasis syndrome in patients with acute cerebral infarction.
目的探讨急性脑梗死患者血浆纤溶酶原激活物抑制物(PAI)、D-二聚体、血栓调节蛋白(TM)变化与中医痰证、血瘀证变化的关系。
4)  Plasminogen activator inhibitor 1
纤溶酶原激活物抑制物
1.
Objective To study the changes of tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), and soluble thrombomodulin (sTM) induced by dengue 2 virus (D 2V) infection of vascular endothelial cells.
方法 应用D2 V感染生长良好的第2、3代脐静脉内皮细胞以观察内皮细胞在表达组织纤溶酶原激活物(tPA)、纤溶酶原激活物抑制物1(PAI 1)、凝血酶调节蛋白(TM)等分子变化。
5)  Plasminogen activator inhibitor-1
血浆纤溶酶原激活物抑制物-1
1.
Objective:To investigate the relationship between plasminogen activator inhibitor-1(PAI-1) activity and PAI-1 promoter 4G/5G polymorphism and insulin resistance(IR) in olderly diabetes.
目的探讨老年糖尿病患者血浆纤溶酶原激活物抑制物-1(PAI-1)活性及基因启动子区4G/5G多态性与胰岛素抵抗(IR)的关系。
6)  PAI-1
血浆纤溶酶原激活物抑制物-1
1.
Methods The 4G/5G allele polymorphi sm in the PAI-1 gene promoter region were genetyped by allele specific PCR in 10 8 type 2 diabetes with or without hypertriglyceridemia and 40 normal controls.
目的 探讨伴高甘油三酯血症的2型糖尿病患者血浆纤溶酶原激活物抑制物-1 (PAI-1) 活性变化及机制。
2.
Methods The 4G/5G allele polymorphism in the PAI-1 gene promoter region were genetyped by allele specific PCR in 108 type 2 diabetes with or without hypertriglyceridemia and 40 normal controls.
目的:探讨2型糖尿病合并高甘油三酯血症患者血浆纤溶酶原激活物抑制物-1(PAI-1)活性的变化及与基因启动区单核苷酸插入/缺失(4G/5G)多态性和胰岛素抵抗(IR)及甘油三酯的关系。
补充资料:纤溶酶原激活剂
分子式:
CAS号:

性质:是一组蛋白酶,使纤溶酶激活生成有活性的纤溶酶。它们主要包括:(1)组织纤溶酶激动剂(tPA),一种丝氨酸蛋白酶,创伤或应激时从血管内皮释放入血,只有同纤维蛋白结合时才有激活纤溶酶原的活性;(2)尿激酶,对纤维蛋白选择性较低,是某些内皮细胞系合成、经外分泌管道(如肾小管)分泌,可能参与清除沉积在管道内的纤维蛋白;(3)链激酶,临床上用于裂解纤维蛋白,其选择性较差,可作用于液相中的纤溶酶原,也可作用于纤维蛋白血块中的纤溶酶原,链激酶不是蛋白酶,但与纤溶酶原结合成复合物后构象改变,显示蛋白水解酶活性。

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