BACKGROUND & OBJECTIVE: PC-1 gene is highly expressed in C4-2 cell line, an androgen-independent and aggressive prostate cancer cell line, but lowly expressed in LNCaP cell line, an androgen-dependent prostate cancer cell line.

Androgen responsive element decoy DNA inhibits the promoter of prostate specific antigen and induces apoptosis of LNCaP cells;

Effects of small interfering RNA on CXCR4 expression in LNcap cells;

Key words:prostate cancer;matrine;LNCaP cells;androgen receptor;prostate specific antige

[Methods] LNCaP cells and PC-3 cells were treated with genistein and daidzein at varying doses to evaluate viability by use of 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium(MTT).

Its promoter activity was determined with dual-luciferase reporter assay after it had been cloned into pGL3-basic vector and transfected into LNCaP cells.

Objectives: To investigate the androgen receptor (AR) isoforms expression in human benign and malignant prostatic tissues and LNCaP cells.

Expression of CXCR4 protein and mRNA in 3 bladder cancer cell lines in vitro;

Establishment of human lung squamous carcinoma cell line CHLH-1;

Establishment of a mammalian cell line stably expressing TAT fusion protein;