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1)  Antisense RNA
反义核酸
1.
Inhibitory Effect of Antisense RNA Targeting survivin Gene Combined with Taxotere on Transplanted Multidrug Resistant Colorectal Carcinoma in Nude Mice;
生存素反义核酸联合泰素帝治疗荷耐药结肠癌移植瘤裸鼠的初步观察
2.
Antisense RNA targeting survivin enhances the chemosensitivity of LOVO/Adr cells to taxotere;
生存素反义核酸增加人结肠癌对泰素帝的化疗敏感性
3.
Increased sensitivity of HeLa cells to UV radiation and chemotherapy drug cisplatin by antisense RNA of DNA-PKcs;
DNA-PKcs反义核酸增强HeLa细胞对辐射及化疗药物顺铂的敏感性
2)  Antisense [英][,ænti'sens]  [美][,ænti'sɛns, ,æntaɪ-]
反义核酸
1.
Human Antisense VEGF_(121) Expression Vector Inhibits Angiogenensis Potential of Pancreatic Cancer Cell in vitro;
血管内皮生长因子_(121)反义核酸抑制人胰腺癌细胞体外促血管生成能力
2.
Observation in the Antisense TRP1 Transfected Melanocytes and Malignant Melanoma Cells by Microscope and Electron Microscope;
TRP-1反义核酸转染黑素细胞 黑素瘤细胞的光镜及电镜观察
3.
Influence on Apoptosis in the Antisense TRP-1 Transfected Melanocytes and Malignant Melanoma Cells;
TRP-1编码基因反义核酸对良恶性黑素细胞凋亡的影响
3)  antisense nucleic acid
反义核酸
1.
Objective To examine the inhibitory effect of antisense nucleic acid on the in vitro translation of esterase mRNA from dipterex resistant Culex pipiens pallens .
目的 用反义核酸抑制抗敌百虫淡色库蚊扩增酯酶mRNA体外翻译。
2.
Vascular endothelial cells in which the expression of vWF is inhibited effectively can be constructed using antisense nucleic acid technology.
为降低在血栓形成早期血管内皮细胞分泌的血管性血友病因子(vWF)对凝血级联反应的触发效应,利用反义核酸技术构建降低vWF表达量的血管内皮细胞。
4)  Antisense oligodeoxynucleotide
反义核酸
1.
Effect of bcl-2 antisense oligodeoxynucleotide mediated by jetPEI-RGD on colon carcinoma cell line caco-2;
聚乙烯亚胺-整合素配体复合物介导bcl-2反义核酸对结肠癌细胞的作用
2.
Some explants were cultured in the presence of antisense oligodeoxynucleotide targeted to cbfa1 mRNA.
目的:采用反义核酸技术,用特异的与cbfa1mRNA互补的AS ODN抑制cbfa1在体外培养牙胚的翻译,利用电镜及ALP、OC等指标观察其对牙齿发育及矿化的影响,探讨其在牙齿发育中的作用。
3.
In the control experiment, explants were cultured in agarose semi-solid medium under serum-free and chemically defined conditions, while explants in the other group were cultured with 30 μmol/L, 15 bp antisense oligodeoxynucleotide targeted to DSPP mRNA.
方法 胎龄为 17dBalb C胎鼠上颌第一磨牙 ,分为 2组 ,对照组牙胚置于无血清BGJb半固定培养基中培养 ;DSPP反义核酸组牙胚置于含有30 μmol L ,长 15bp的DSPP反义寡核苷酸的半固体培养基中培养。
5)  antisense oligonucleotide
反义核酸
1.
Effects of intracellular and extracellular concentrations of calcium ions in odontoblast cell line MDPC-23 by antisense oligonucleotide against dentin matrix protein 1;
牙本质基质蛋白1基因反义核酸对MDPC-23细胞内、外钙离子浓度的影响
2.
Effect of antisense oligonucleotide against dentin matrix protein 1 on ALP ase activity and mineralization ability of odontoblast cell line MDPC-23;
牙本质基质蛋白1基因反义核酸对MDPC-23细胞碱性磷酸酶活性和矿化能力的影响
3.
Objective To investigate the effect of nuclear factor kappa B(NF-κB) antisense oligonucleotide (AS-ON) on cardiac muscle myosin isoenzymes (MI) and serum cytokines (TNF-α, IL-1β, Fas) expressions in rat models of chronic heart failure.
目的:探讨核转录因子(nuclear factor kappa B, NF-κB)反义核酸(antisense oligonucleotide,AS-ON)对慢性心力衰竭(chronic heart failure,CHF)病程心肌肌凝蛋白同功酶(myosin isoenzyme,MI)和细胞因子肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)和Fas的影响。
6)  antisense oligodeoxynucleotides
反义核苷酸
1.
Aim To investigate the feasibility of transfer antisense oligodeoxynucleotides(AS-ODNs) by the phospholipids-based gas-filled microbubbles(PGM) under ultrasound activation.
方法应用PGM将结合荧光蛋白的反义核苷酸片段ZL转染到乳腺癌细胞SK-BR-3中,考察不同因素如:ZL浓度、PGM浓度、超声持续时间和机械指数(M I)等对ZL转染率及细胞存活率的影响。
补充资料:免疫核酸 ,免疫核糖核酸
药物名称:免疫核糖核酸

英文名:Immune RNA

别名: 免疫核酸 ,免疫核糖核酸
外文名:Immune RNA
适应症:
临床适应证与转移因数相似。目前主要用于恶性肿瘤如肾癌、肺癌、消化道癌及神经母细胞瘤和骨肉瘤等的辅助治疗,也曾试用于慢性乙型肝炎和流行性乙脑,可使部分细胞免疫功能低下的病人恢复正常。
用量用法:
1.治肿瘤:用法尚不统一,一般多采用皮下注射或静滴。剂量仍在探索中。皮下注射:多注射于淋巴引流区的皮下,如腋下或腹股沟,可每周注射3~5次,连续2~3个月。静滴:溶于5%葡萄糖液中滴注。 2.治慢性肝炎:每周注射1次,每次1支(正常人周围血白细胞iRNA,每支含量3mg;正常人脾血白细胞iRNA,每支含量2mg);疗程一般为4~6个月。6个月以上者改为2周注射1次,最长为1年。
注意事项:
各单位试制的iRNA含量很不一致,但至少应含10000000000免疫活性细胞提取物。iRNA本身无特殊反应,但由于制备过程不同,有的产品含有微量蛋白,故应注意过敏反应,应由低剂量开始应用。


类别:免疫增强剂
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