1) Schimdt-Claisen condensation
Schimdt-Claisen缩合
2) Claisen condensation
Claisen酯缩合
1.
Sodium diethyl oxalacetate was prepared by Claisen condensation of diethyl oxalate with ethyl acetate.
以乙酸乙酯和草酸二乙酯为原料,经交叉Claisen酯缩合反应合成2-氧代丁二酸二乙酯钠盐,用此盐与苯肼在酸性条件下进行加成缩合反应制得苯腙,再经闭环、酸化可制得1-苯基-3-羧酸乙酯-5-吡唑啉酮。
2.
Sodium diethyl oxalacetate was prepared by Claisen condensation with acetic and oxalic acid esters.
以乙酸乙酯和草酸二乙酯为原料 ,经交叉Claisen酯缩合反应合成钠代草酰乙酸乙酯 。
3) Claisen condensation
Claisen缩合
1.
Two new β-diketones containing trifluoromethyl groups,4,4,4-trifluoro-1-(6-methoxynaphthalen-2-yl)butane-1,3-dione and 4,4,4-trifluoro-1-(4-phenylmethoxyphenyl)butane-1,3-dione were synthesized from aromatic ketones and ethyl trifluoracetate by the classical Claisen condensation reaction using CH3ONa as the strong base.
芳香酮和三氟乙酸乙酯在强碱CH3ONa作用下发生经典Claisen缩合反应,合成了两种未见文献报道的含氟β-二酮:4,4,4-三氟-1-(6-甲氧基-2-萘基)-1,3-二酮和4,4,4-三氟-1-(4-苄氧基苯基)-1,3-二酮。
2.
Two UV-A ultraviolet absorbents:1-(4-methoxy-phenyl)-3-phenylpropane-1,3-dione and 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl) propane-1,3-dione were synthesized from aromatic ketone and ester by classical Claisen condensation using NaNH_2 as strong alkali.
通过芳香酮和芳香酯在强碱NaNH2条件下的Claisen缩合反应,合成了两种β-二酮类化合物1-(4-甲氧基苯基)-3-苯基-1,3-二酮与1-(4-甲氧基苯基)-3-(4-叔丁基苯基)-1,3-二酮,并通过元素分析、紫外光谱、红外光谱和核磁共振对其组成与结构进行了确证和表征。
3.
In the reaction process,the intermediate phenyl-1-nitrilebenzylketone obtained by Claisen condensation in basic condition was not separated from the reaction mixture,but used directly to synthesize the targeting molecule by hydrolyzing in 48% HBr solution.
以苯乙氰和苯甲酸甲酯为起始原料,在碱性条件下,采用Claisen缩合合成中间产物苯基-1-氰基苄基甲酮,不经分离,直接在48%氢溴酸水溶液中水解脱羧得到苯基苄基甲酮,产率为92。
4) Claisen-Schmidt condensation
Claisen-Schmidt缩合
1.
Piperonylene propanal was synthesized through Claisen-Schmidt condensation reaction in the presence of KF/Al2O3,heliotropin and propanal as reactants.
KF Al2O3作催化剂,催化洋茉莉醛和丙醛进行Claisen-Schmidt缩合反应合成了亚胡椒基丙醛。
2.
A series of substituted-2 -hydroxychalcone in yields of 48%～90% were synthesized by Claisen-Schmidt condensation from substituted 2 -hydroxyhypnone and substituted benzaldehyde under room temperture.
取代-2′-羟基苯乙酮与取代苯甲醛在室温下经过Claisen-Schmidt缩合,合成了一系列取代2′-羟基查尔酮类化合物(3a~3w,其中3d~3w为新化合物),收率48%~90%,其结构经1H NMR和IR表征。
3.
Via Claisen-Schmidt condensation and hydrogenation reaction, raspberry ketone was synthesized by using p-hydroxybenzaldenhyde as the main raw material.
本文以对羟苯甲醛为主要原料,通过Claisen-Schmidt缩合、加氢还原二步反应合成覆盆子酮;根据气味分子结构理论设计、合成了四个覆盆子酮类似物,采用红外光谱、核磁共振及质谱等分析方法对合成产物的结构进行了表征,并经调香师对其进行评香,确定这些化合物具有作为香料的应用前景。
5) Claisen condensation
Claisen缩合反应
1.
In acid or basic condition the recyclization of the opening product was carried out, and spirocyclic and bridged compounds 11～14 were obtained by intramolecular Claisen condensation.
经retro-aldol重排,环加成产物3开环生成取代环己烯4,在酸和碱性介质中对开环产物进行再环合,经分子内Claisen缩合反应形成螺环和桥环化合物11～14。
6) Claisen-Schmidt condensation reaction
Claisen-Schmidt缩合反应
1.
Investigation on activity of Claisen-Schmidt condensation reaction for different substituted benzaldehyde compounds;
不同取代芳醛Claisen-Schmidt缩合反应活性研究
2.
Investigation of Claisen-Schmidt condensation reaction using near-critical water as media indicated that the reaction can be carried out in near-critical water without any added catalyst.
对近临界水中苯甲醛与丙酮的Claisen-Schmidt缩合反应的研究表明,在没有外加任何催化剂的条件下,苯甲醛与丙酮可顺利地发生缩合反应,近临界水在其中兼作溶剂和催化剂,避免了碱催化剂的使用和随后繁杂的中和、分离步骤以及产生废弃盐等弊端。
补充资料：Claisen-Schmidt reaction
分子式：
CAS号：
性质：芳香族醛与脂肪族或脂肪芳香族的醛、酮、腈类等在氢氧化钠水溶液或醇钠的催化作用下发生缩合，形成α-及β-不饱和醛、酮或腈，称为克莱森-施密特反应。硝基化合物也可发生类似反应，产物经催化还原即得到在植物碱合成中重要的原料β-苯乙胺类。
CAS号：
性质：芳香族醛与脂肪族或脂肪芳香族的醛、酮、腈类等在氢氧化钠水溶液或醇钠的催化作用下发生缩合，形成α-及β-不饱和醛、酮或腈，称为克莱森-施密特反应。硝基化合物也可发生类似反应，产物经催化还原即得到在植物碱合成中重要的原料β-苯乙胺类。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条