Methods Urine samples were hydrolyzed with sodium hydroxide, and deuterium-labeled THC-COOH (Δ9-d9-THC-COOH) was added as internal standard; then the solution was extracted with n-hexane-ethyl : acetate(9:1), dried, solved with 100μL acetonitrile, and analyzed by liquid chromatograph coupled to tandem mass-spectrometry (LC/MS-MS).

Rapid determination of tobacco-specific nitrosamines in cut tobacco by SPE-LC/MS/MS;

Simultaneous determination of four tobacco-specific nitrosamines in cigarette mainstream smoke by LC/MS/MS;

Determination Simvastatin in Plasma by LC/MS/MS and Pharmacokinetic Studies of Simvastatin Tablet in Healthy Volunteers;

The serum concentrations of glibenclamide and metformin were determined by an validated LC-MS/MS and HPLC.

Determination of the Residues of Doxycycline in Eggs with LC-MS/MS;

Determination of Sulfonamides Residues in Milk by LC-MS/MS;

The extraction solution was passed through an aluminiumoxid-SPE cartrige for clean-up and then determined by LC-MS/MS.

OBJECTIVE To establish an identification method by LC-MS/MS and a quantification method by HPLC for phenolphthalein added illegally into the diet food for reducing weight.

Pharmacokinetics and bioavailability study of fluoxetine hydrochloride capsules in Chinese healthy volunteers by LC-MS/MS method;

LC-MS/MS determination of budesonide in dog plasma;

Objective A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed to quantitate and confirm the presence of malachite green and leucomalachite green in water using isotope internal standard dilution technique.