Conclusion rAAV-cdk5-siRNA-GFP can lower the expression of cdk5 gene effectively,reduce the number of axonal spheroids,delay the death of Purkinje neurons and attenuate the hyperphosphorylation of cytoskeletons in npc mice significantly.

The results revealed that in npc-1 mouse brain, many enlarged neurons containing lipids, pathological axonal spheroids were fou.

To investigate pathogenesis of pathological axonal spheroids in Niemann-Pick disease type C(NPC), a murine model of NPC, the Balb/c nih npc-1 mouse strain, has been studied using immunohistochemicaland immunoblot techniques, to explore activation of cdk4/cyclin D1/Rb2 pathway and its association withneurodegeneration and hyperphosphorylated neurofilament.

Considering Murray\'s vector solutions of the Earth figure axis,principles and methods to select a suitable celestial reference pole were investigated,visualized analysis and discussions to select celestial ephemeris pole,celestial intermediate pole and non-rotating origin were presented.

During the development of nervous system,axons are guided along specific pathways by different classes of guidance cues in the extracellular environment.

(Methods: Cultured) rat superior cervical ganglia were treated with DMSO(100%,10 μl) per well to disconnect axons from the cell bodies.

Stained with HE, the regenerated nerve axons and cross section area w.

The Study of Chemotaxis Induced by Nerve Growth Factor or Ciliary Neurotrophic Factor on Sciatic Nerve Axon Regeneration of Rats;

Autophagic role of neuron axon during regeneration of rat sciatic nerves;

Signal transduction in axon guidance and growth;