1) Bispecific single-chain antibody
双特异性单链抗体
1.
After having successfully constructed and expressed the gene of the anti-CD3/anti-CD20 bispecific single-chain antibody (bscCD3×CD20), here we analyzed its in vitro bioactivity of mediating the lysis of Ramous human B-lymphoma cells in the presence of T-enriched human peripheral blood lymphocytes (PBL).
在构建并成功表达抗CD3/抗CD20双特异性单链抗体(bscCD3×CD20)的基础上,对其在体外介导T淋巴细胞杀伤Ramous B淋巴瘤细胞的生物活性进行了分析。
2.
The synthetic gene with 1640bp encoding for the anti-CD3 /anti-CD20 bispecific single-chain antibody was designed and obtained by SOE (sp licing by overlap extension) PCR.
设计并合成多个 6 0bp左右的DNA小片段 ,经重叠延伸PCR扩增获得 16 4 0bp的抗CD3 抗CD2 0双特异性单链抗体完整基因片段 ,将其克隆入真核定点表达载体pcDNA5 FRT中 ,脂质体法转染Flp_InTM CHO细胞 ,获得稳定表达细胞株 ,目的蛋白在上清中的表达量约为 30 0 μg L。
3.
Bispecific antibodies including bispecific shingle-chain antibody?leucine zipper dimerized bispecific ScFv antibody? bispecific single-chain antibody-toxin are very useful bilolgical products to be used in the clinical diagnosis and therapy developed in recent years, here we mainly elaborate the research progress of the gene construction?linker design?expression products and their bio-activity.
双特异抗体特别是双特异性单链抗体、亮氨酸接链双特异性抗体、双特异性单链抗体毒素等是近几年来发展起来的很有前途的监床诊疗生物制剂 ,本文对其基因构建、边接肽设计、表达产物及活性等方面的新进展作了重点论述。
2) Single-chain bispecific antibody(sc-BsAb)
单链双特异性抗体
3) bispecific single-chain antibody-oxin
双特异性单链抗体毒素
5) single chain Fv antibody aganst prostate cancer specific antigen
前列腺癌特异性抗原单链抗体
6) anti-IgG-anti-HRP bispecific monoclonal antibody(BsMcAb)
抗人IgG-抗HRP双特异性单克隆抗体
补充资料：双特异性单克隆抗体
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性质：即杂交的杂交瘤(hybrid hybridoma)是将杂交瘤与其他抗原免疫的脾细胞或另一种杂交瘤融合的结果。
CAS号：
性质：即杂交的杂交瘤(hybrid hybridoma)是将杂交瘤与其他抗原免疫的脾细胞或另一种杂交瘤融合的结果。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条