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1)  DNA topoisomerases-Ⅱ
DNA拓扑异构酶-Ⅱ
2)  TopoisomeraseⅡ
DNA拓扑异构酶Ⅱ
1.
Objective To examine the expression of Glutathione-s-transferase-π(GST-π),TopoisomeraseⅡ(TopoⅡ),Estrogen receptor(ER),Progesterone receptor(PR) in breast carcinoma tissues and study on clinical relationship between GST-π,TopoⅡ,ER and PR in breast carcinoma.
目的检测谷胱甘肽-S-转移酶-π(GST-π)、DNA拓扑异构酶Ⅱ(TopoⅡ)及雌、孕激素受体(ER、PR)在乳腺癌组织中的表达,分析其在乳腺癌临床病理特征间的关系。
2.
[Objective]To study clinical significance of topoisomeraseⅡ(TopoⅡ),proliferating cell nuclear antigen(PCNA) expression in gastric mucosal of chronic atrophic gastritis(CAG) patients.
目的观察慢性萎缩性胃炎(CAG)患者胃黏膜标本中DNA拓扑异构酶Ⅱ(ToPoⅡ)和增殖细胞核抗原(PCNA)的表达及意义。
3)  DNA topoisomerase Ⅱ
DNA拓扑异构酶Ⅱ
1.
Expression and Significance of DNA Topoisomerase Ⅱin Esophageal Carcinoma;
DNA拓扑异构酶Ⅱ在食管癌的表达及意义
2.
Expression of P-glycoprotein, DNA topoisomerase Ⅱ, glutathione S-transferase π in malignant digestive canal carcinomas;
消化道恶性肿瘤组织中P糖蛋白、DNA拓扑异构酶Ⅱ及谷胱甘肽转移酶π亚型的表达
3.
Objective:To evaluate the clinicopathological significance of expressions of c-erbB-2,p53,proliferating cell nuclear antigen(PCNA),DNA topoisomerase Ⅱ(TopoⅡ),estrogen receptor(ER) and progesterone receptor(PR) in breast cancer.
目的:探讨c-erbB-2、p53、增殖细胞核抗原(proliferating cell nuc lear antigen,PCNA)和DNA拓扑异构酶Ⅱ(DNAtopoisom eraseⅡ,TopoⅡ)及雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)在乳腺癌的表达和临床病理关系。
4)  DNA topoisomerase
DNA拓扑异构酶Ⅱ
1.
Objective To investigate the relationship between the expression of glutathione-s-transferase-π (GST-π),P-glycoprotein (P-gp) and DNA topoisomerase (Topo Ⅱ) and pathological characteristics and prognosis and multi-drug resistance in colorectal cancer.
目的探讨大肠癌组织中谷胱甘肽S转移酶(GST-π)、糖蛋白(P-gp)和DNA拓扑异构酶Ⅱ(TopoⅡ)的表达与临床病理和预后及多药耐药的关系。
5)  Topoisomerase II(Topo-Ⅱ)
DNA拓扑异构酶Ⅱ(Topo-Ⅱ)
6)  DNA topoisomerase Ⅱalpha
DNA拓扑异构酶Ⅱ-α
1.
Expression of glutathione S-transferase-πand DNA topoisomerase Ⅱalpha and their implications in colorectal carcinoma;
谷胱甘肽-S-转移酶π和DNA拓扑异构酶Ⅱ-α在结直肠癌组织中的表达及其意义
补充资料:DNA拓扑异构酶抑制剂
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性质:一类能够抑制DNA拓扑异构酶活性的化合物。DNA拓扑异构酶参与催化各种遗传过程中DNA链的断开和再连接。DNA拓扑异构酶抑制剂有助于研究异构酶的作用方式和功能,已发现许多这种抑制剂可作为抗肿瘤药,如鬼臼素(epipodophyllotoxins)等一些拓扑酶Ⅱ的特异性抑制剂。

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