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1)  aripiprazole orally disintegrating tablet
阿立哌唑口腔崩解片
1.
Bioavailability of aripiprazole orally disintegrating tablet in healthy volunteers;
阿立哌唑口腔崩解片在健康人体的生物利用度
2)  Azithromycin oral rapidly disintegrating tablets
阿奇霉素口腔崩解片
3)  domperidone orally disintegrating tablet
多潘立酮口腔崩解片
1.
Bioequivalence of domperidone orally disintegrating tablets in healthy volunteers;
多潘立酮口腔崩解片在健康人体的生物等效性
4)  orally disintegrating tablets
口腔崩解片
1.
Preparation and dissolution of orally disintegrating tablets of huperzine A;
石杉碱甲口腔崩解片的制备及溶出度考察
2.
Preparation and Quality Control of Nimesulide Orally Disintegrating Tablets;
尼美舒利口腔崩解片的制备及质量检查
3.
Trial-manufacturing of the Granisetron Hydrochloride orally disintegrating tablets;
盐酸格拉司琼口腔崩解片的试制
5)  oral disintegrating tablets
口腔崩解片
1.
Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets;
盐酸三氟拉嗪口腔崩解片的处方筛选及体外溶出度
2.
The formula of breviscapine oral disintegrating tablets and its preparation;
灯盏花素口腔崩解片的制剂处方和制备工艺的研究
3.
Preparation and quality control of meloxicam oral disintegrating tablets;
美洛昔康口腔崩解片的制备及质量控制
6)  Orally disintegrating tablet
口腔崩解片
1.
Bioequivalence of ambroxol hydrochloride orally disintegrating tablets in healthy volunteers;
盐酸氨溴索口腔崩解片的人体生物等效性
2.
Disintegration behavior of ibuprofen microcrystal from orally disintegrating tablets;
布洛芬微晶体在口腔崩解片中的应用
3.
Relative bioavailability and bioequivalence of ibuprofen orally disintegrating tablets in healthy volunteers;
布洛芬口腔崩解片的人体相对生物利用度和生物等效性
补充资料:比哌立登
分子式:C21H29NO
分子量:311.45
CAS号:514-65-8

性质:该品为结晶体。熔点112-116℃(101℃)。不易溶于水,微溶于乙醇,易溶于甲醇。该品的盐酸盐(C21H29NO·HCI)又称安克痉(Akineton,Akinophyl),为白色结晶。约275℃分解,也有报道其熔点为238℃。

制备方法:以环戊二烯为原料,先与氯乙烯合成氯代双环庚烯,再与镁和乙醚反应,得双环庚烯镁化氯,最后与β-哌啶苯丙酮缩合制得比哌立登。β-哌啶苯丙酮的制备:以苯乙酮为原料与哌啶盐酸盐、甲醛、二甲胺经曼氏反应得到。

用途:该品为抗震颤麻痹药、解痉药。小鼠口服LD50为545mg/kg,静脉注射为56mg/kg。

说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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