METHODS Afloquanone was prepared,taking 2-aminio-(5-nitrobenzoic) acid as initial material,followed by condensation,reduction,protection,annulation,halogen exchange,and deprotection,totally in 7 steps.

Simultaneous Determination of Sulfonamides and Fluoroquinolones Residues in Pork by Solid-phase Extraction and High Performance Liquid Chromatography;

Interactions Between Fluoroquinolones and Bovine Serum Albumin by Fluorescence Method and Affinity Capillary Electrophoresis;

Mutant prevention concentration of fluoroquinolones for Baumannii acinetobacter and its ciprofloxacin induced mutant strains;

The action mechanism of DNA Gyrase with the tittled compounds,selection and the structure- activity relationships of fluroquinolones are reviewed.

Objective Shigellosis was investigated among outpatients with diarrhea in Wuhan, serotype distribution and drug resistance of Shigellae was analyzed, the mechanism of fluroquinolones-resistant was studied and a genotyping method for Shigella spp.

Relation between fluoroquinolones-resistant and mutation of grlA and grlB gene in Staphylococcus aureus;

Synthesis and antibacterial activities of 7-{4-[2-[2-substituted-4-((5S)-5-acetylaminomethyl-2-oxo-oxazolidin-3-yl)-phenyl]-ethyl]-piperazin-1-yl}-fluoroquinolones;

A Study on the Difference of Efflux Protein Expression between Klebsiella Pneumoniae Used in Vitro Fluoroquinolone and Ones Not Used;