OBJECTIVE To investigate the protection of tetramethylpyrazine nicolate on oxidative damage in both primary cortical cells and human neuroblastoma cells line(SH-SY5Y).

Preparation of tetramethylpyrazine phosphate pulsed-release tablets;

Preparation of tetramethylpyrazine phosphate sustained-release tablets;

Effect of cyclodextrins on the intranasal absorption of tetramethylpyrazine phosphate;

Study on preparation of ligustrazine hydrochloride liposome;

Preparation of oral timed release pellets of ligustrazine hydrochloride;

Uniform design method for optimizing proportion of transdermal penetration enhancers of ligustrazine hydrochloride;

Objective To investigate the absorption characteristic of tetramethylpyrazine phosphate(TMPP) in various intestinal segments.

Study on Bioequivalence of Ligustrazine Phosphate Capsules in Healthy Volunteers;

Determination of Ligustrazine Phosphate for Injection by HPLC;

Preparation and in- vitro drug release of Ligustrazine Phosphate Sustained- release Patches;

[Objective] To study the effects of Borneol-Menthol binary eutectic mixture on transdermal permeation of tetramethylpyrazine hydrochloride(TMPH)and to investigate the feasibility of traditional chinese medicine(i.

hy926 as a model to analyze the activity changes of relative enzymes and regulation mechanism of relative signal pathways of the model under the condition of injury by angiotensin II (AngII) and / or protection by tetramethylpyrazine hydrochloride (TMP·HCl), an effective component of traditional Chinese medicine Ligusticum chuanxiong Hort.

Aim To determine the concentration and dynamic chan ge s of tetramethylpyrazine hydrochloride in the retinal tissue following intraperi toneal injection in rabbits.