1) synonymous mutation
同义突变
1.
Methods A synonymous mutation and a hybrophobic polypeptide linker(Gly_(4)Ser)_(3) were used to splice three different gene fragments of β2m and HLA-A2 extracellular region subunits by overlap-PCR for constructing single chain β2m-HLA-A2-BSP fusion gene in vitro.
方法应用重叠延伸PCR(overlap-PCR)对编码HLA-A2的cDNA序列进行一个碱基的同义突变,并将β2m和HLA-A2胞外段亚单位两段编码序列的cDNA通过一疏水性多肽接头(Gly4Ser)3的DNA序列进行前后拼接,并利用引物所带的BSP编码序列,构建单链β2m-HLA-A2-BSP融合基因,将测序正确的β2m-HLA-A2-BSP融合基因插入原核表达载体pET-22b中,转化BL21(DE3)细菌,SDS-PAGE检测其表达,融合蛋白于体外抗原肽存在条件下稀释复性后由Western blot鉴定其空间构象。
2) nonsense mutation
无义突变
1.
The nonsense mutation is a specific type of gene mutation.
无义突变(nonsense mutation)是一类特定类型的基因突变。
2.
Method 1 Targeted correction of nonsense mutation in LDLR in HepG2 cell 1.
方法 1 HepG2细胞LDLR基因无义突变模型原位修复 1。
3.
Conclusions:Two novel missense mutaions and one nonsense mutation in the LQTS genes are identified in 5 LQTS families.
其中HERG基因无义突变Y616X引起mRNA表达量减少,可能受无义突变介导的RNA降解(Nonsense Mediated Decay,NMD)机制有关,从而引起较轻微的临床症状。
3) Missense mutation
错义突变
1.
One of the etiological factors of digestive tract cancers in Chinese: the missense mutation Val384Asp in the hMLH1 gene;
中国人消化道肿瘤发病的遗传背景因素——错配修复基因hMLH1错义突变Va1384Asp
2.
So far, 25 ATP1A2 gene mutations have been identified, and most of them are missense mutations.
目前已鉴定出25种ATP1A2基因突变,且绝大部分为错义突变,这些突变或者引起Na+/K+-ATP酶α2亚基单个等位基因的功能丧失,或者引起钠钾泵的动力学改变。
3.
Objective To investigate whether there are as so ciations between missense mutation of renin gene and essential hypertension(EH).
目的 肾素基因错义突变与原发性高血压的相关性。
4) mutations in both
同时突变
5) generalized catastrophe theory
广义突变论
6) missense mutant
错义突变型
补充资料：同义突变
分子式：
CAS号：
性质： 密码发生突变，但所编码的氨基酸不变，而表型相同的基因型突变。
CAS号：
性质： 密码发生突变，但所编码的氨基酸不变，而表型相同的基因型突变。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条