1) ATP sensitive potassium channel activation
KATP通道开放剂
2) KATP opener
KATP开放剂
1.
Aim To investigate the effect of chronic hypoxia on the expression of KATP channel subtype’s mRNA in pulmonary arterial smooth muscle of rats and the effects of new KATP opener iptakalim.
目的研究慢性低氧对大鼠肺动脉平滑肌KATP通道mRNA表达的影响及新型KATP开放剂埃他卡林(Iptakalim,IPT)的作用。
3) K ATP channel blockers
KATP通道阻断剂
1.
The investigations on selectivity, reciprocity, effect-site and mutual accommodation of those channels will possibly faciliate the reevaluation of some related drugs and instruct the development of K ATP channel blockers and openers with high selectivity.
通过对调节KATP通道药物的选择性、可逆性、作用位点以及相互调节的研究,可以对一些临床用药进行重新评估,并指导开发高选择性的KATP通道阻断剂和开放剂。
4) KATP channels
KATP通道
1.
Method In HEK-293 cells expressing different recombinant KATP channels(Kir6.
目的研究埃他卡林新衍生物对不同亚型KATP通道的选择性作用。
5) KATP channel
KATP通道
1.
[Objective] To investigate the effect of KATP channel on ischemic preconditioning.
目的探讨KATP通道在缺血预适应(ischemicpreconditioning,IP)中所起的作用。
2.
Aim To investigate the effect of chronic hypoxia on the expression of KATP channel subtype’s mRNA in pulmonary arterial smooth muscle of rats and the effects of new KATP opener iptakalim.
目的研究慢性低氧对大鼠肺动脉平滑肌KATP通道mRNA表达的影响及新型KATP开放剂埃他卡林(Iptakalim,IPT)的作用。
3.
Conclusions Levosimendan 300nmol/L can protect myocardium from ischemia/reperfusion injury by openning the KATP channel in isolated rat heart.
结论:300nmol/L Levo对离体大鼠心肌缺血—再灌注损伤有保护作用,其可能的机制是开放KATP通道。
6) K_(ATP) channel
KATP通道
1.
Objective To study the currents of K_(ATP) channels(I_(K(ATP))) in primary cultured sinoatrial node(SAN) cells in neonatal rats during simulated ischemia,and to provide the protective experiment basis for ischemic SAN cells.
目的观察模拟缺血对原代培养乳鼠窦房结细胞膜KATP通道电流的影响,为保护缺血窦房结细胞提供实验依据。
2.
To detect the expression of K_(ATP) channel subunits on rat airway smooth muscle cells and rat bronchia smooth muscle cells,we used RT-PCR.
为检测大鼠肺动脉平滑肌及支气管平滑肌中KATP通道亚基的表达情况 ,应用RT -PCR技术 ,从原代培养的Wistar大鼠肺动脉平滑肌及支气管平滑肌细胞第 3- 5代提取总RNA ,逆转录 ,并进行PCR扩增鉴定 ,发现肺动脉平滑肌细胞有Kir6 。
补充资料：钙通道阻滞剂
钙通道阻滞剂
calcium channel blockers
又称“钙拮抗剂”、“慢通道阻滞剂”。指能选择性的阻滞细胞膜上的钙通道，减少Ca2+经钙通道内流的一类药物。主要有二氢吡啶类(如硝苯吡啶、尼莫地平）苯烷胺类(如维拉帕米）和硫氮■类(如硫氮■酮）等。在钙通道蛋白上有此三类药物的高亲和力结合位点。具有扩张血管、降低血压、减弱心肌收缩力和抑制血小板聚集等作用。主要用于治疗冠心病、高血压病、室上性心动过速、脑血管疾病等。不同药物对不同部位组织有相对选择性，如硝苯吡啶扩张冠状血管作用比较显著，而尼莫地平扩张脑血管作用较强。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条