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1)  Urokinase-type plasminogen activator system
尿激酶型纤维酶原激活物系统
2)  urokinase-type plasminogen activator
尿激酶纤溶酶原激活物
1.
Aim: To investigate the expression of urokinase-type plasminogen activator (uPA) in human colorectal carcinoma tissue and its relation to the neovascularization.
目的检测大肠癌组织中尿激酶纤溶酶原激活物(uPA)及微血管密度(MVD)。
2.
The protein level of urokinase-type plasminogen activator (uPA) was also determined by western blotting.
采用Western blot方法检测癌细胞尿激酶纤溶酶原激活物(uPA)蛋白水平。
3.
Besides,the protein level of urokinase-type plasminogen activator(uPA) was also determined by Western blot assay.
另外,采用Western blot方法检测癌细胞尿激酶纤溶酶原激活物(urokinase-type plasminogen activator,uPA)蛋白变化。
3)  urokinase-type plasminogen activator
尿激酶型纤维蛋白溶酶原激活剂
1.
Objective: To study the effects of genistein on the expression of urokinase-type plasminogen activator (uPA) and the activity of protein tyrosine kinase (PTK) in MDA-MB-453 cells, and explore the molecular mechanism of anti-angiogenesis in HER-2/neu-overexpressing breast cancer by genistein.
目的: 观察染料木黄酮(亦称三羟异黄酮,genistein,Gen)对MDA-MB-453乳腺癌细胞尿激酶型纤维蛋白溶酶原激活剂(urokinase-type plasminogen activator,uPA)表达及蛋白酪氨酸激酶(protein tyrosine kinase,PTK)活性的影响,探讨Gen抗HER-2/neu高表达乳腺癌血管生成的分子机制。
4)  urokinase type plasminogen activator
尿激酶型纤维蛋白溶酶原激活剂
1.
Objective To explore the inhibitory effect of genistein on oncogene HER-2/neu-overexpressing breast cancer xenograft tumors and its relationship with urokinase type plasminogen activator (uPA) expression.
目的 探讨三羟异黄酮(genistein)对原癌基因HER 2 neu高表达乳腺癌异种移植瘤的抑制作用及其与尿激酶型纤维蛋白溶酶原激活剂(urokinasetypeplasminogenactivator ,uPA)表达变化的关系。
5)  urokinase-type plasminogen activator
尿激酶型纤溶酶原激活物
1.
Urokinase-type plasminogen activator with its inhibitor and liver fibrosis;
尿激酶型纤溶酶原激活物及其抑制物与肝纤维化
2.
Relationship between the prognosis of chronic severe hepatitis and the expression of urokinase-type plasminogen activator;
尿激酶型纤溶酶原激活物的表达与慢性重型肝炎预后的相关性
3.
Clinical significance of urokinase-type plasminogen activator system in patients with malignant tumor of digestive tract;
消化道肿瘤患者血浆尿激酶型纤溶酶原激活物系统的变化及其意义
6)  uPA
尿激酶型纤溶酶原激活物
1.
Expression of osteopontin and uPA in gastric carcinoma tissue;
胃癌组织中骨桥蛋白与尿激酶型纤溶酶原激活物的表达
2.
The Expression of uPA and Endostatin in Human Colorectal Carcinoma and Their Relations to Angiogenesis;
人大肠肿瘤中尿激酶型纤溶酶原激活物和内皮抑素的表达与血管新生的关系
3.
Objective To explore the expression of nuclear factor kappa B(NF-κB) and urokinase-type plasminogen activator(uPA) in human cerebral gliomas and their effect on the invasive growth and malignant development of human cerebral glioma.
目的研究人脑胶质瘤中核转录因子-κB(NF-κB)和尿激酶型纤溶酶原激活物(uPA)的表达,探讨二者在胶质瘤侵袭性生长和恶性进展中的作用。
补充资料:乙酰化纤溶酶原-链激酶激活剂复合物
药物名称:乙酰化纤溶酶原-链激酶激活剂复合物

英文名:APSAC

该药对血块有选择性高亲和力且半衰期长,清除半衰期为70分钟,故纤维蛋白溶解作用缓慢而持久。用药后5-8小时仍可维持有效溶栓血药浓度,有报告作用维持7-10天,而SK用药后3小时血中即完全清除,因此可视为长效SK。

APSAC用药特点是短RV间内一次给予全部剂量。据报告冠状动脉内溶栓5分钟内注射5-30mg,1-4小时后闭塞动脉再通率为70-83%。静脉给药5分钟内注入5-30mg,再通率为60-100%。该药全身纤溶作用微弱,用药简单,药物作用时间长,然而再闭塞率可达20%,但平均再闭塞率仍较SK、rt-PA为低。


类别:溶栓药
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