Advance in synthesis of chiral intermediate for diltiazem

Aim To develope a new asymmetric synthetic method of a key chiral intermediate for the synthesis of salmeterol.

In this paper,optimal processes were achieved by using glyoxylate as raw material,which reacted with 1(-)menthyl to synthesis chiral intermediate.

Aim:To establish an HPLC method to determine the ee values and content of two β-aminoalcohol chiral drug intermediates in bioconversion broth.

The appearance of interval debulking surgery seems to bring hope to the patients,however,its benefit is still controversal according to recent reports.

Aluminosilicate active intermediate was synthesized by heating fly coal ash with sodium hydroxide at 550 °C and by hydrolysis, study on dye decolourization.

The stability of the active intermediates, bend length of monoene and conjugated diene were discussed.

The mechanism was mainly attributed to the formation of the cyclic nitrogenated fullerene active intermediate C 60 NH from the fragmentation of aminatied fullerene derivatives by the UV laser desorption ionization,the C 60 NH is very easy to aggregate with C 60 and itself to form C 84 N 2,C 120 NH,C 180 N 2H 2,C 240 N .