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1)  Ⅳ collagenase
Ⅳ胶原酶
1.
Methods Based on the present methods,to perfusate the liver in vivo at first,then perfusate and digest the liver with type Ⅳ collagenase ex vivo,after that,the Kupffer cells were separated by density gradient centrifugation with percoll separating medium and cultured.
方法参照国内外文献方法加以改良,采用前灌流液在体灌流肝脏后,再用Ⅳ胶原酶离体灌流消化,Percoll分离液行密度梯度离心分离库普弗细胞,贴壁培养;锥虫蓝测定细胞活度,并用荧光显微镜、免疫组织化学以及吞噬功能实验行细胞纯度鉴定。
2)  type IV collagenase
Ⅳ型胶原酶
3)  Type Ⅳcollagenase
Ⅳ型胶原酶
1.
BACKGROUND &OBJECTIVE: Invasion and metastasis are significant ch ar acteristics of cancer cells, Type Ⅳcollagenase (matrix metalloproteinase-2, an d-9) plays an important role in cancer invasion and metastasis.
背景与目的:侵袭转移是恶性肿瘤细胞的重要特性,Ⅳ型胶原酶(包括基质金属蛋白酶2和基质金属蛋白酶9)在恶性肿瘤转移扩散中发挥着极其重要的作用。
2.
Type Ⅳcollagenase, w hich is a key member of MMPs family, has been viewed as a promising target in tu mor study.
背景与目的:基质金属蛋白酶(matrixmetalloproteinases,MMPs)在肿瘤生长和转移的多个环节发挥着重要作用,Ⅳ型胶原酶作为MMPs家族的重要成员之一已成为肿瘤研究的新靶点。
4)  Type Ⅳ collagenase
Ⅳ型胶原酶
1.
An Evaluation of sCD44v6 and Type Ⅳ Collagenase in Malignant Ascites;
可溶性CD44v6和Ⅳ型胶原酶在恶性腹水中的诊断价值
2.
Expressions of type Ⅳ collagenase in human brain gliomas;
人脑胶质瘤Ⅳ型胶原酶的表达
3.
To investigate the relationship of metastasis in hum an colorectal cancer with type Ⅳ collagenases.
目的 :探讨人大肠癌转移与Ⅳ型胶原酶的关系。
5)  Type Ⅳ collagen
Ⅳ型胶原
1.
Effect of compound Rhizoma Coptidis capsule on expression of transforming growth factor-β_1 and type Ⅳ collagen proteins in renal tissue of diabetic rats with nephropathy;
复方黄连胶囊对糖尿病肾病大鼠肾组织TGF-β_1与Ⅳ型胶原蛋白表达的影响
2.
Effects of fluvastatin on the expression of connective tissue growth factor and type Ⅳ collagen in mesangial cells induced by transforming growth factor-β1;
氟伐他汀对转化生长因子β_1诱导的系膜细胞结缔组织生长因子和Ⅳ型胶原表达的影响
3.
Correlation between urinary transforming growth factor beta1&type Ⅳ collagen and the lesion of early diabetic nephropathy along with the intervene effect of Cozaar;
尿TGF-β1、Ⅳ型胶原与早期糖尿病肾损害及科素亚的干预作用
6)  Collagen Ⅳ
Ⅳ型胶原
1.
The Effect of TGF-β_1 in Mediating Collagen Ⅰ and Collagen Ⅳ Synthesis in Neonate Rat Cultured Cardiac Fibroblasts;
TGF-β_1对新生大鼠心肌成纤维细胞Ⅰ型和Ⅳ型胶原合成的影响
2.
TGF-β1 Mediates Collagen Ⅰ and Collagen Ⅳ Synthesis in Neonate Rat Cultured Cardiac Fibroblasts;
TGF-β1介导新生大鼠心肌成纤维细胞Ⅰ型和Ⅳ型胶原合成的研究(英文)
3.
Expressions of transforming growth factor-β_1 and collagen Ⅳ in renal tissues of patients with chronic allograft nephropathy;
TGF-β_1和Ⅳ型胶原在慢性移植肾病患者肾组织中的表达及意义
补充资料:胶原酶
分子式:
CAS号:

性质: 又称骨胶原酶,简称胶原酶。由溶组织梭菌(Clostridum histolyticum)制取而得。最适pH值7~8。具有独特的消化天然胶原和变性胶原能力。去污剂、六氯环己烷和重金属离子可降低酶活性。专一作用于原胶原,使其断裂进而被其他蛋白酶水解,不水解纤维蛋白,球蛋白。主要局部外用于烧伤,尚可用于治疗溃疡、浓疮、脊椎软骨增生。

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