1) replication-defective adenovirus
非增殖型腺病毒
1.
Part One Reconstruction and identification of the replication-defective /replication-competent virus expressing lipocalin 2 gene Objective To reconstruct replication-selective oncolytic adenovirus and replication-defective adenovirus,which can both express lipocalin 2 gene.
一、携带Lipocalin 2的靶向溶瘤腺病毒和非增殖型腺病毒的构建和鉴定 目的:构建携带人Lipocalin 2基因且删除E1B55基因的溶瘤腺病毒和携带Lipocalin 2的非增殖型腺病毒。
2) Replication-defective adenovirus
非增殖腺病毒
1.
Methods Replication-defective adenovirus plasmid containing human CTLA4-Ig recombinant fusion gene was constructed and linearized,then cotransfected with an intact supercoiled Ad backbone plasmid,named pAdEasy,into E.
目的研究携带人细胞毒T淋巴细胞相关抗原(CTLA)4-Ig融合基因的非增殖腺病毒载体的生物学特性。
3) conditionally replicating adenovirus
增殖型腺病毒
1.
Infection of tumor cells with conditionally replicating adenovirus results in tumor-specific replication,subsequent oncolysis and release of the virus progeny.
增殖型腺病毒能在肿瘤细胞中复制并裂解肿瘤细胞,释放出的子代病毒再感染邻近肿瘤细胞直至完全杀灭肿瘤,却不影响正常细胞的功能。
4) Replication competent adenovirus
增殖型腺病毒
1.
Methods Replication competent adenovirus and replication competent adenovirus mediated interleukin 12 gene was constructed and expanded separately.
目的研究携带白介素12(mIL-12)基因的增殖型腺病毒CNHK200-mIL-12对胃癌细胞株化疗敏感性的影响。
2.
Objective:To construct a replication competent adenovirus vector carrying human endostatin gene,looking for an effective method for the therapy of colon cancer.
目的 :构建携带内皮抑素基因的增殖型腺病毒载体 ,寻找结肠癌的有效治疗方法。
5) replicate adenovirus
增殖腺病毒
1.
Objective The selective replicate adenovirus was used to express mouse interleukin 12 (mIL12) in order to enhance the therapeutic effects on the nasopharyngeal carcinoma (NPC).
目的 肿瘤选择性增殖腺病毒携带小鼠白细胞介素 1 2 (mIL1 2 )基因 ,增强对鼻咽癌细胞的杀伤作用。
6) conditionally replicating adenovirus
肿瘤增殖型腺病毒
1.
Objective To construct the conditionally replicating adenovirus vector Ad-delE1b55kD-shRNA/Survivin-EGFP that can transfects into HT-29 effectually and selectively and contains shRNA targeting to human Survivin gene.
目的构建特异性强,转染率高,针对人Survivin进行RNA干扰的肿瘤增殖型腺病毒载体(Ad-delE1b55kD-shRNA/Survivin-EGFP)。
2.
Objective To Construct the conditionally replicating adenovirus vector Ad-delE1b55KD-shRNA/Survivin-EGFP which can transfect to HT-29 effectually and selectively and containing shRNA to human Survivin gene.
目的:构建特异性强,转染率高,携带针对人Survivin的shRNA的肿瘤增殖型腺病毒载体,研究其介导的以人Survivin为靶标的RNA干扰对结肠癌细胞株HT-29中Survivin mRNA和蛋白的表达、对结肠癌细胞HT-29增殖和凋亡的影响、时效性及其意义,探讨肿瘤增殖型腺病毒介导RNA干扰对结肠癌的治疗作用。
补充资料：非甲非乙型病毒性肝炎
非甲非乙型病毒性肝炎
病名。病毒性肝炎类型之一。详见该条。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条