NMR STUDIES OF CHINESE GINSENOSIDE-ReⅠ．2D NMR Study of Ginsenoside-Re;

The configurations of the four geometric mer-isomers in a new [Co(3,3-tri)(ibn)Cl]2+ (3,3-tri = N-(3-aminoethyl)-l,3-propanediamine; ibn = 1,2-diamino-2-methylpropane) system were assigned by using 2D NMR techniques such as gCOSY and NOESY.

The configurations of the four geometric mer - isomers in a new [Co(3,3 - tri) (amp)Cl]2+ [3,3-tri = N - (3 - aminoethyl) - 1,3 - propanediamine; amp = 2 - (aminomethyl)pyridine] system were assigned by using 2D NMR techniques such as gCOSY and NOESY.

The intermediate was purified through extraction and crystallization and characterized by mass spectra, element analysis, Fourier transform infrared spectra and ~1H nuclear magnetic resonance spectroscopy, the result indicats that the intermediate of the reaction is 5-amino-naphthalene-1-carbamate (ANC) with a molecular weight of.

1H NMR (nuclear magnetic resonance), 13 C NMR, distorsionless enhancement by polarization transter (DEPT) and a series of 2D NMR techniques, including heteronuclear multiple quantrum correlation (HMQC), heteronuclear multiple bond correlation (HMBC) and 1H-1H correlation spectrometry (COSY), were applied to assign all carbon and proton signals of the product.

The ultraviolet spectrum,infrared spectrum,1D and 2D nuclear magnetic resonance (1H NMR,13 C NMR,1H-1H COSY,HMQC and HMBC) spectra and mass spectra of new drug lomerizine dihydrochloride were reported and interpreted.