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1)  Microsomal glutathione transferase 1
微粒体GST1
2)  Solid particle
固体微粒
1.
The composition of solid particle and influence on interfacial tension between organic phase and water phase were investigated at different pH by using XRD and interfacial tension instrument.
为查清紫金山铜矿溶剂萃取铜过程界面乳化的原因,采用X射线衍射和界面张力等现代分析检测手段,考察了铜溶剂萃取过程中固体微粒的组成和来源以及不同pH值条件下不同种类的固体微粒对有机相-水相间界面张力的影响。
2.
The effects of solid particles on stability of interfacial emulsion in copper solvent extraction was studied.
对铜溶剂萃取时萃原液中固体微粒稳定界面乳化液的机理进行了研究。
3.
In order to investigate the influence of the solid particle on the zincous electrlbath's voltage and the quality and output of depositing zinc in zinc electrowinning,two different type of filters are introduced to carry out the filtration experiment of electrolysis mixture liquid.
指出悬浮在电解混合液中的固体微粒主要是钙和锶的不溶物、SiO2 及少量MnO2 。
3)  microsome [英]['maikrəsəum]  [美]['maɪkrə,som]
微粒体
1.
Spectral Analysis and Study of the Microsome Cytochrome P450 Aromatase of Thais clavigera;
疣荔枝螺微粒体细胞色素P450酶系的光谱分析
2.
Effect of oxidation products of fatty acids in microsomes from pork on oxymyoglobin oxidation in vitro;
猪肉微粒体脂肪酸氧化产物对氧合肌红蛋白氧化的影响
3.
Effect of Fructus Lycii in Xinjiang on the peroxidation damage model in microsome;
新疆枸杞子对大鼠肝微粒体脂质过氧化损伤体外模型的影响
4)  solid particles
固体微粒
1.
For solid particles being the most deleterious matter in lubricating oils,the dielectrophoresis separation process system for removing the solid particles was established.
针对润滑油中危害最大物质之一的固体微粒,建立了润滑油介电动力学分离流态实验装置系统,研究了该方法主要工艺技术参数:电场强度和流速等。
2.
In order to avoid the formation of the third phase during the process of solvent extraction of copper,the composition of the solid particles in the third phase was examined by XRD as well as adsorption and degradation of the extractant caused by the solid particles were investigated by IR and GC-MS methods.
采用X射线衍射、傅立叶变换红外光谱、气-质联用色谱等分析检测手段研究了铜萃取过程中第三相固体微粒的组成、固体微粒对萃取剂的吸附和降解作用,寻求抑制铜萃取过程中第三相形成的方法。
5)  microparticulate system
微粒体系
1.
Theinfluencing factors on the microparticulate system are explored with reference to the application of microparticulate retention system composedof cationic polyacrylamide and bentonite in the production of printing and writing paper.
在本文中,主要结合阳离子聚丙烯酰胺和膨润土组成的微粒助留体系在文化纸生产中的应用情况,对微粒体系的影响因素进行探讨。
6)  liver microsomes
肝微粒体
1.
CYP3A1/2 and 2C9/10 in rat liver microsomes mediate 22α-and 24-hydroxylation of 18α-glycyrrhetic acid;
大鼠肝微粒体CYP3A1/2和CYP2C9/10参与甘草次酸羟化代谢
2.
Determination of puerarin in rat liver microsomes by LC-MS and its pharmacokinetics;
大鼠肝微粒体中葛根素的液相色谱-质谱测定法及药物代谢动力学
3.
Gender difference in ranolazine metabolism in rat liver microsomes;
盐酸雷诺嗪在大鼠肝微粒体内代谢的性别差异
补充资料:肝微粒体药物代谢酶
分子式:
CAS号:

性质:肝脏微粒体中含有多种酶系统,是许多药物、杀虫剂、除草剂、污染物及食物添加剂等外源性高脂溶性物质在体内的主要生物转化场所,也称为肝微粒体药物代谢酶,简称为肝药酶。该酶系统底物面广,活性个体差异大,影响活性因素多。其中最重要的是混合功能氧化酶系统,可催化许多不同型的氧化反应,如羟基化,烷基化,脱氨基化,脱卤素,硫原子氧化等。该酶系统中一个主要成分是细胞色素P450,是由与一氧化碳结合后,在光谱450nm处有吸收峰而得名。细胞色素P450含量高低反映了混合功能氧化酶系统活性的高低,这个系统将分子氧中一个氧原子氧化药物,另一个氧原子生成水,没有产生相应的还原物,故也称为细胞色素单加氧酶。肝药酶主要生物学意义是使大多数药物转化后降低或消失活性,极性增加,易于排出体外。少数药物经生物转化后可产生药理活性,如环磷酰胺,在细胞色素P450催化下氧化成4-羟基环磷酰胺,开环后变成磷酰胺氮芥才有烷化作用。个别药物如非那西丁,经转化生成对氨基苯乙醚,毒性加大。也有少数化合物如多环芳香烃经转化可成为有致癌及致突变的中间体。

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