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1)  trisphosphate inositol
肌醇三磷酸
1.
Phospholipase C-rl is activated in response to the complex of the epidermal growth factor-receptor by the mechanism of tyrosine phosphorylation, and the second messengers diacylglycerol and trisphosphate inositol are generated through hydrolyzation of phosphatidylinositol-4,5-bisphosphate.
表皮生长因子(epidermal growth factor,EGF)与细胞膜上的表皮生长因子受体(epidermal growth factor receptor,EGFR)特异性结合后,使磷脂酶C-gammal(phospholipase C-γ1,PLC-γ1)发生酪氨酸磷酸化激活,水解细胞膜上的磷脂酰肌醇二磷酸(phosphatidylinositol-4,5-bisphosphate,PIP_2)生成第二信史分子二酰基甘油(diacylglycerol,DAG)和肌醇三磷酸(trisphosphate inositol,IP_3),其中IP_3通过作用于内质网膜上特异的IP_3受体引起内质网上ca~(2+)释放,DAG则通过激活蛋白激酶C(protein kinase C,PKC),以磷酸化的形式对许多蛋白和酶进行修饰,从而调控一系列生理过程。
2)  IP3
三磷酸肌醇
1.
Objective To explore the role of 1, 4, 5-trisphosphate inositol ( IP3) and bax gene expression in apoptosis of HepG2 cells induced by Quercetin.
目的探讨三磷酸肌醇(IP3)和bax基因表达变化在五羟黄酮(Quercetin)诱导肝癌细胞凋亡中的作用。
2.
The activity of protein kinase A (PKA) and protein kinase C (PKC) in the NS-1 cells were determined by phosphoration of histone, and the level of inositol trisphosphate (IP3) was measured with the method of radioimmunoassay.
方法:用不同浓度甲硫氨酸脑啡肽(methionine enkep-halin,MENK)及抗δ阿片受体单克隆抗体处理小鼠的骨髓瘤细胞(NS-1),采用组蛋白磷酸化法测定NS-1细胞蛋白激酶A(PKA)和蛋白激酶C(PKC)的活性,并采用放射免疫分析法测定其三磷酸肌醇(IP3)的含量。
3)  inositol(1,4,5)-trisphosphat
三磷酸肌醇
1.
Effect of inositol(1,4,5)-trisphosphate on intracellular calcium in rat detrusor cells;
激光共聚焦显微镜观察三磷酸肌醇对大鼠逼尿肌细胞内钙的影响
4)  IP_3
三磷酸肌醇
1.
Objective To observe the effect of tumor necrosis factor-alpha(TNF-α) on the content of the second signal messenger such as cyclic adenosine monophosphate(cAMP),cyclic guanosine monophosphate(cGMP) and inosito-1,4,5 triphosphate(IP_3) in pulmonary fibroblast in rats.
目的观察不同浓度的肿瘤坏死因子-α(TNF-α)作用于大鼠肺成纤维细胞不同的时间对细胞内信号物质三磷酸肌醇(IP3)、环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)的影响。
2.
Ca~ (2+ ) ? DAG ?IP_3 and cAMP were second messengers of signal transduction in plant cell.
介绍了植物细胞信号转导中的主要第二信使钙离子、三磷酸肌醇、二酯酰甘油、环腺苷酸的研究进展 ,特别对它们的产生及其在信号转导中的地位和作用进行了重点介绍。
5)  IP 3
三磷酸肌醇
1.
The number of stool,the amplitude change of circular muscle strips,the length of cell and [Ca 2+]i of colonic smooth muscule,the change of IP 3 and serum NO were observed in the two groups.
观测 2组大鼠 1h排便的粪点数、2组结肠平滑肌环行肌条振幅、平滑肌细胞长度及钙离子的变化 ;测定平滑肌细胞三磷酸肌醇 (IP3 )和血清一氧化氮 (NO)含量的变化。
2.
The activity of protein kinase A(PKA) and protein kinase C(PKC),and the level of inositol trisphosphate(IP 3) were measured.
为了探讨阿片肽与细胞表面受体结合后所产生的生物效应及其机制 ,用不同浓度甲硫氨酸脑啡肽 ( MENK)及抗 δ阿片受体单克隆抗体处理小鼠的骨髓瘤细胞 ( NS- 1 ) ,然后测定蛋白激酶A( PKA) ,蛋白激酶 C( PKC)活性及三磷酸肌醇 ( IP3 )含量 。
6)  inositol trisphosphate
三磷酸肌醇
1.
Effects of ganoderma lucidum polysaccharides on inositol trisphosphate and diacylglycerol in murine T cells;
灵芝多糖对小鼠T细胞三磷酸肌醇和二酰基甘油体外作用的研究
2.
The effects of API 0134 (API) on the occlusive thrombosis time (OT), platelet aggregation function, level of blood platelet activiting factor (PAF), content of inositol trisphosphate (IP 3 ) and expression of IP 3 receptor of platelets were observed.
观察穿心莲成分 API0 1 34 (API)对闭塞性血栓形成时间 (OT)、血小板聚集、血液血小板活化因子 (PAF)含量、血小板内三磷酸肌醇 (IP3)含量和 IP3受体 (IP3R)表达的影响。
补充资料:磷脂酰肌醇三磷酸
分子式:
CAS号:

性质:又称三磷酸磷脂酰肌醇,4,5-二磷酸磷脂酰肌醇。是磷脂类化合物之一,前体是磷脂酰肌醇二磷酸。在脑中含量很多,与其前体在体内可互相转换。通常可从牛脑中提取,产品多为其铵盐或钠盐,呈淡黄色冻干粉。R1和R2的脂肪酸组成:16:0约1%;18:0约41%;18:1约30%;18:3约4%;18:4约1%;20:4约1%;20:5约2%;20:6约14%。早期取平均值把R1定为硬脂酸,R2定为花生四烯酸,与实际误差较大。主要用作生化试剂。

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