Objective To investigate whether laser speckle imaging technique can be used to monitor the changes of spinal cord hemodynamics.

Speckle images are produced by the reflected and scattered light beams from rough surface through free-space to observing plane when laser illuminates the object surface.

Study on the dependence of the contrast of image speckles produced by strong scattering-object on random surface and imaging system;

In this paper, the influence of the incidence angle on the free space Fraunhofer speckle and the image speckle is analysed in detail.

Two-dimensional coordinate system between exit pupil plane and image plane is set up,detailed expressions of transverse autocorrelation function of image speckle light intensity and normalized autocorrelation function ase achieve.

Laser speckle contrast imaging (LSCI) provides full-field and real-time investigation of microcirculation blood flow in vivo with high spatiotemporal resolution, including several advantages, such as non-contact, noninvasive and high speed imaging.

Laser speckle contrast imaging (LASCI) technique is a non-scanning image technique, resulting measurements of the regional blood flow with high spatial and temporal resolution.