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1)  4-(4-Chlorophenyl)-1,2,3,6-tetrahydropy-ridine
4-(4-氯苯基)-1,2,3,6-四氢吡啶
2)  4-Phenyl-1,2,3,6-tetrahydropyridine
4-苯基-1,2,3,6-四氢吡啶
3)  1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-甲基-4-苯基-1,2,3,6-四氢吡啶
1.
Objective To explore the possible role of neural cell adhesion molecule(NCAM) in mediating the protective effect of glial cell line-derived neurotrophic actor(GDNF) on dopaminergic(DA) neurons in the mesencephlic cell culture injured by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).
目的研究神经细胞黏附分子(neural cell adhesion molecule,NCAM)在胶质细胞系源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)保护1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)损伤的多巴胺(dopamine,DA)能神经元中的作用。
2.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal models are ideal models of human Parkinson s disease, in terms of neurobiochemical and histopathological changes, as well as behavioral disorders.
用神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)制备的动物模型,无论在神经生化和病理组织学特征,还是在运动行为表现方面都酷似人帕金森病(PD),是目前研究PD的理想模型。
3.
Objective To investigate the neuroprotective effects of a sapogenin from Rhizoma Anemarrhenae(ZMR) on nigrostriatal dopaminergic neurons in chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-lesioned mouse model.
目的研究知母活性成分ZMR对慢性1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)损伤小鼠模型黑质纹状体通路多巴胺神经元的影响。
4)  N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)
N-甲基-4-苯基-1,2,3,6-四氢吡啶
5)  MPTP
1-甲基-4-苯基-1,2,3,6-四氢吡啶
1.
Objective To investigate the immune response of the substantia nigra in the MPTP-induced model of Parkinson’s disease(PD), and explore the regulation of ganoderma spore oil on the inflammatory response induced by MPTP.
目的研究1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)所致帕金森病模型中脑黑质区的免疫应答情况,探讨灵芝孢子油对MPTP引起的神经炎症反应的调节作用。
2.
Objective: To investigate the neuroprotective effects and mechanisms of Chunxiong Chatiao pulvis(CXCT) on the MPTP-induced dopaminergic neurodegneration in mice model of PD.
目的:研究川芎茶调散对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)致小鼠多巴胺(DA)神经元损伤的保护作用,并从抗氧化角度探讨其神经保护作用的可能机制。
6)  1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)
1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)
补充资料:4-(4-氯苯基)-1,2,3,6-四氢吡啶
分子式:C11H12ClN
分子量:193.68
CAS号:30005-48-4

性质:沸点167-170℃/1kPa。

制备方法:可用对二氯苯与丙酮在镁粉参与下加成,生成(4-氯苯基)二甲基甲醇氯化镁,然后水解得(4-氯苯基)二甲基甲醇,继而将后者在硫酸氢钾参与下减压加热脱水,得1-甲基-1-(4-氯苯基)乙烯,进而与甲醛、氯化铵环合即得该品。

用途:氟哌啶醇的中间体。

说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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