Spectral data analysis and structural elucidation of Cefmenoxime Hydrochloride;

Determination of polymers in cefmenoxime hydrochloride by sephadex G-10 column method

To improve the yield and quality of cefmenoxime hydrochloride,this paper describes the paticular synthetic process of cefmenoxime hydrochloride(Ⅳ).

METHODS: A randomized, comparative, single-blind, multicenter clinical trial of domestic cefmenoxime hydrochloride injection (test) and cefmenoxime hydrochloride injection (Bestcall) made in Japan (control) in the treatment of respiratory and urinary tract infections were conducted.

Determination the contents of residual volatile organic solvents of N-Methyl-pyrrolidine in Cefepime dihydrochloride by HPLC;

A sensitive and specific identification method of E isomer impurity in raw drug of Z cefepime dihydrochloride was established with high performance liquid chromatography/tandem-time of flight(HPLC/(Q-TOF)) mass spectrometry technology.

Comparative study of two methods for determination of N-methylpyrrolidine in cefepime hydrochloride;

Quantitative determination of high molecular weight impurities in cefepime hydrochloride injection by Sephadex G-10 column chromatography;

Efficacy of cefepime hydrochloride for injection in treatment of acute bacterial infections;

A Multi-center Randomized Controlled Clinical Trial on Effects of Domestic and Imported Cefepime in Treatment of Lower-respiratory Tract and Urinary Tract Infections;

Determination of residual methanol,ethanol and acetone in Cefepime by GC;

One new synthetic method of cefepime dihydrochloride using 7-amino-3[(1-methyl-1-pyrrolidino)methyl]ceph-3-em-4-carboxylate hydrochloric salt and diethylphosphoryl(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetate as the starting materials was developed with high yield,low impurities,and low cost etc.