1) antiepileptics and anticovulsants
抗癫痫及抗惊厥药
3) anticonvulsant
[英][,æntikən'vʌlsənt] [美][,æntikən'vʌlsənt, ,æntaɪ-]
抗惊厥药
1.
Clinical study of 19 patients with drug hypersensitivity syndrome by anticonvulsant;
抗惊厥药所致药物超敏综合征19例临床特征分析
2.
Lacosamide,an anticonvulsant was synthesized from D-serine by protection with(Boc)_2O, O-methylation with(CH_3)_-2SO_4 and amidation with benzylamine in presence of DCC to give(R)-2-Boc-amino-3- methoxy-N-benzyl propionamide,which was subjected to deprotection and acetylation with an overall yield of about 60%.
D-丝氨酸经Boc保护、硫酸二甲酯O-甲基化、DCC作用下经苄胺酰胺化得到(R)-2-叔丁氧羰基氨基-3-甲氧基-N-苄基丙酰胺,再经脱Boc保护和乙酰化反应制得抗惊厥药拉科酰胺,总收率约60%。
4) antiepileptic
['ænti,epi'leptik]
抗癫痫药
1.
Synthesis of the antiepileptic tiagabine hydrochloride;
新型抗癫痫药盐酸噻加宾的合成
2.
Starting from tetrafuran, 2_(4_Aminosulfonylphenyl)_4H_1,2_thiazine_1_dioxide, an antiepileptic drug with special structure, was obtained via esterification, sulphonation, chloridization, condensation and cyclization.
以四氢呋喃为原料 ,经酯化、磺化、酰氯化、缩合、环化等步骤 ,合成了化学名为 4_(四氢_2H_1,2_噻嗪基_2 )苯磺酰胺_S_S_二氧化物的抗癫痫药舒噻嗪 (sulthiame) ,通过IR、1HNMR和元素分析对其结构进行了表
3.
Lamotigine is a new and specific antiepileptic.
拉莫三嗪是一种新型的特效抗癫痫药，我国对该药的应用完全依赖于从英国进口。
5) antiepileptic drug
抗癫痫药
1.
Gabapentin hydrochloride, an antiepileptic drug, was synthesized by Knoevenagel reaction from cyclohexanone and acetonitrile, Michael addition reaction, Pd-C catalytic hydrogenation and hydrolysis to give 2-hydroxy-2-azaspiro[4.
5]癸烷-3-酮,再经RaneyNi催化氢化还原和水解、成盐制得抗癫痫药盐酸加巴喷丁,总收率14%。
2.
Objective:The results of serum concentration monitoring of 4 antiepileptic drugs with 357 measurements in 164 epilepsy children were evaluated in order to guide clinical rational administration of these antiepileptic drugs.
目的:回顾性分析4种常用抗癫痫药在儿童癫痫治疗中的血药浓度监测情况,以利指导合理用药。
6) antiepileptics
抗癫痫药
1.
Advance in research of fetal malformations induced by antiepileptics;
抗癫痫药致胎儿畸形的研究进展
2.
Effect of hemolysis in antiepileptics plasma sample determined by FPIA;
溶血现象对抗癫痫药血药浓度测定的影响
补充资料：抗惊厥药
用以控制惊厥的药物。惊厥是全身骨髓肌强烈的不随意收缩、中枢神经系统的过度兴奋状态。常见于儿童高热、子痫、破伤风、脑膜炎、癫痫大发作、中枢兴奋药中毒等。大剂量镇静催眠药有抗惊厥作用，常用于抗惊厥的药物有苯巴比妥钠、异戊巴比妥，也可用硫喷妥钠。水合氯醛、副醛保留灌肠也有抗惊厥作用。抗焦虑药安定有中枢抑制作用及中枢性肌肉松弛作用，静脉注射时有抗惊厥作用，可用于癫痫持续状态。镁离子有中枢抑制作用和阻断神经肌肉接头的作用，故可抗惊厥。常用硫酸镁肌肉注射或静脉滴入。硫酸镁不如巴比妥类安全可靠，因此临床上多为巴比妥类取代。但子痫时仍有应用(见妊娠高血压综合征)。也可用于破伤风惊厥及其他惊厥。肌注25％的硫酸镁注射液常用量为10ml，静脉滴注时,将25％注射液10ml用葡萄糖液稀释为1％的溶液后，缓慢滴入。硫酸镁用量过大或注射过快可出现呼吸抑制、血压下降、心率减慢直至心跳停止，故应避免静注而采用肌注或静滴。若发生硫酸镁中毒,应静注10％葡萄糖酸钙10ml。肾功能不全者慎用。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条