To synthesize disodium norcantharidate(DSNC) as the test drug; 2.

Preparation and cytotoxicity of polylactic acid-polyethylene glycol nanoparticles loaded with norcantharidin;

Preparation and Characterization of Solid Lipid Nanoparticles of Norcantharidin;

Improved synthesis of norcantharidin;

Structural Identification of Sodium Demethylcantharidate by IR and MS;

In vitro and in vivo assesemet of sodium norcantharidin lipid microsphere;

The effect of sodium norcantharidate(SNCTD) on drug-resistant associated genes expression in cisplatin(DDP) resistant human lung adenocarcinoma cell line A549/DDP

[Purpose]To investigate the reversal effect of sodium norcantharidate(SNCTD)on cisplatin-resistant human pulmonary adenocarcinoma cell line A549/DDP and the effect on the drug resistant cell cycle.

Eighteen compounds were synthesized by the reaction of 5,6 dehydronorcantharidin with substituted aromatic amine.

Studies on Reaction of α Aminoalkylphosphonic Diphenyl Ester and Norcantharidin, 5,6 Dehydronorcantharidin and exo bicyclo 2.2.1 hept 5 ene 2,3 dicarboxylic Anhydride;