An experimental study on osteoblast proliferation activity of coral hydroxyapatite and pure-phase beta-tricalcium phosphate

Objective:To study the efects of coral hydroxyapatite andβ-tricalcium phosphate on the activity of osteoblast proliferation so as to evaluate the biocompatibility of the biomaterials at the cell level,and supply experimental evidences on selecting artificial bone material in tissue engineering.

Directional differentiation culture of human bone marrow mesenchymal stem cells on surface exchanging coralline hydroxyapatite;

The clinical results of one-stage implantation of coralline hydroxyapatite with XIVE implants.;

The artificial joint material of UHMWPE composite reinforced with coralline hydroxyapatite(CHA) in different contents was prepared by the pressing formation method.

Objective To observe the long-term effect of tissue engineering-based repair of large weight-bearing bone defect in goats, and the final outcome of the scaffold material coral hydroxyapatite (CHAP) in vivo.

27 caprines were divided into three groups: group A (the defect was filled with coral hydroxyapatite CHAP); group B (the defect was filled with CHAP + bone marrow stroma cell BMSc); group C (the defect was filled with CHAP +BMSc + fascia flap).

We studied the biological features ofbone mesenchymal stem cells (BMSCs) of rabbits, and observed the effect ofrepairing rabbit skull defects by 10% coral hydroxyapatite (CHA) embedded withBMSCs.