Myocardial hypoxia imagings provide noninvasive approaches for the detection of myocardial ischemia, dedication of the potential role of hypoxia in development of angiogenesis and cardiomyopathy by the detection of balance of flow and oxygen consumption.

To observe the feasibility of 99Tcm -HL91 hypoxia imaging to predict the radiosensitization of hyperbaric oxygenation, the mice bearing H22 tumor KM were placed into hyperbaric oxygen chamber for a certain time, and were divided into three groups of 15 min, 30 min and 60 min, according to the time of being out of hyperbaric oxygenation.

Methods Twenty bearing H22 tumor KM mice were randomly divided into 4 groups,5 mice/group: The control group: only to carry on 99m Tc-HL91 hypoxia imaging.

Objective To study the biological distribution of 99Tcm-EC-MN in tumor models bearing nasopharyngeal carcinoma in vivo and that in vitro,and to explore the clinical significance of 99Tcm-EC-MN in tumor hypoxia imaging.

Objective To evaluate the hypoxia status of tumor pre and after HBO with 99Tcm-HL91 hypoxic image.