AIM and METHODS: To investigate the effects of U50,488H (a selective κ opioid receptor agonist) on cardiac hypertrophy and cardiac cells growth induced by catecholamine.

Antiarrhythmic effect and underlying mechanism of κ-opioid receptor in rats with myocardial ischemia and reperfusion;

Mediative effect of κ-opioid receptor on blood pressure in the rats;

Diuretic mechanism of κ-opioid receptor agonist U50,488H;

Effects of κ-opioid receptor agonist U50488H on the coronary microcirculation and ventricular arrhythmias during myocardial ischemia and reperfusion in rats;

Direct protectory effects of κ-opioid receptor agonist U50488H on myocardial ischemia-reperfusion in rats

Aim: To determine whether activation of κ-opioid receptor with U50,4 88 H, a selective κ-opioid receptor agonist, produces any changes in electrical u ncoupling during prolonged ischemia and whether these changes in electrical unco upling is associated with the cardioprotection induced by κ-opioid receptor ac tivation, and to explore the possible mechanism.

Change of opioid peptide content in plasma and CSF of patients with cerebral hemorrhage and interference effect of Naloxone;

The two-step fermentation conditions of opioid peptide expressed in Pichia pastoris were studied.

The research of opioid peptides already has a history of more than 30 years.

The interac-tion of IL-1,opioid peptides and imrnediateearly genes c-fos and c-jun in rat corticocere-bral cells was studied.

The opioid peptides have extensive physiologic functions such as easing pain,relaxing, regulating immunity, improving appetite, regulating sleeping, restraining the motilityof gastrointestinal and the secretion of peptic and affecting procreation, re.