AIM:To determine the feasibility of combined use of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and empirical proteomic ontology knowledge base (EPO-KB) for identification of serum biomarkers for colorectal cancer.

The first proteomic map database of China will be published by Bioinformation Center and Research Center of Proteomics, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences.

Analysis of protein mass spectra based on multivariate feature fusion visualization;

Despite the deficiency of available human protein databases, the complementarity of human proteins could be got mainly from human genome but not from the protein databases of other organisms.