Aim:Observe the effects of Er-Long-Zuo-Ci-Wan(ELZCW,a compound of Chinese Traditional Medicine) on the spontaneous discharge of external cortex of inferior colliculus(ICx) and secondary auditory cortex(AII) of chronic tinnitus model rats induced by salicylate acid,to explore the neural mechanisms underlying ELZCW preventing tinnitus.

Uses the bold oxygenation level dependent on functional magnetic resonance imaging (BOLD-fMRI) to observe the volume and intensity of the activated auditory cortex evoked by pure tone stimuli in healthy subjects,analyzes the volume and intensity of two hemi- spheres of activated auditory cortex quantitatively,and compares the difference of auditory cortex between left and right hemispheres.

Presynaptic long-term potentiation of synaptic transmission in the pathway from auditory cortex to medial geniculate body;

Projection from amygdaloid complex to auditory cortex in rats;

Expression of NMDA receptor subunit NR1 mRNA during postnatal development of the rat auditory cortex;

Characteristics of frequency response areas of neurons in primary auditory cortex of rats;

Effect of electrical stimulation of the primary auditory cortex on the spontaneous activities of the external nucleus of the inferior colliculus in a rat model of tinnitus induced by salicylate acid

Using conventional extracellular electrophysiological technique,we determined the spatial response areas of neurons in the rat primary auditory cortex(AI) and the features of the spatial response areas.