Studies on virulence mediated by drug resistant Salmonella typhi R plasmid;

Analysis of the relationship between S.typhi R plasmid and the strains survival within macrophages by flow cytometry;

The conjugational transfer and antibiotic resistance expression of S.typhi R plasmid (pR_(ST98)) in different enteric bacilli;

Homology analysis of resistant plasmids in nosocomial infection Escherichia coli;

According to the mechanisms of bacterial drug resistance,many antagonists had been developed and applied,inclu-ding inhibitors of inactive enzymes,accelerators of drug permeation,inhibitors of eflux pump,inhibitors of bacterialbiofilm,synergists of antimicrobial and eliminators of resistant plasmid.

flexneri related to resistant plasmids and detects the way of resistant plasmids transfering among the bacilli through detection of β-lactamase(indluding ESBLs)and tests of S.

The transfer of drug-resistant plasmid from Escherichia coli to pathogenic vibrios was studied by mixed culturing.

The Distribution Types of Foodborne Pathogenic Saimonella in Community Environments and the Experiments of Drug Resistance Elimination

Transformation of Escherichia coli and Bacillus thuringiensis and their plasmid curing by electroporation;

Plasmid curing experiment was carried out by using the sacB positive selection method and plasmid cured derivatives,2020D29,2020D8 and 7653RD were obtained.