There are many big things involved in this.
At least medi-cal bills were not a major concern;
The thinness of the wire was a great problem.
That's not a big problem.
We've run up against a big problem.
There's nothing seriously the matter with your stomach.
The experiment went disastrously wrong, ie progressed in an unexpected way with very unpleasant results.
Snacking can also be a big problem.
A great problem confronted them.
There should be collective leadership in settling major issues.
The air pollution has become a big problem.
Ownership is an important theoretical and practical problem.
The Problem of No Questions:A Vital Issue in the University Education
The difference was not only over the special economic zones but also over the bigger issues,
54. Freshwater issues are a concern for all.
"Basically , NO Pro*em " means BIG pro*em.
a subject scanted in the mass media
The Ambassador's wife went on asking questions,