1.
Is something wrong, Alexandra?
怎么了Alexandra？
2.
What's the matter, Susan?
怎么了， Susan？
3.
Let her do as she likes.
她爱怎么办就怎么办。
4.
What is up with you?
怎么一回事(你怎么了)?
5.
Do whatever is expedient.
怎么便利就怎么办。
6.
What's the blow?
[美、罕]怎么回事？怎么啦？
7.
And what about Michelle?
那Michelle怎么办？
8.
What's going on...buddy?
怎么了...朋友？
9.
- Jesus, what happened to you?
- 靠, 你怎么了?
10.
"What is it, Pumpkin?
“怎么了，小鬼？”
11.
Next morning, the princess opens her eyes.
哎， 怎么the frog is gone?
12.
what of the postscript?"
那么附言怎么样？”
13.
What's the matter with you? You've got a face like a fiddle.
你板着脸，怎么啦？
14.
"How can you say I'm slandering you?
“怎么是我造谣呢！
15.
What about that, eh?
那是怎么回事，呃?
16.
What's the matter with you, Steve?
你怎么了，史蒂夫？
17.
"And of what did he die?"
“他是怎么死的？”
18.
B: How does 5:30 sound?
甲：五点半怎么样?