Five N tetrahydrobenzothiazolyl imines have been synthesized by the condensation of 4,5,6,7 tetrahydro 2 benzothiazolamine with aromatic aldehydes and the reactions of imines respectively, with thioglycollic acid obtained five thiazolidones.

According to the principle of superposition activity, in this article, we have synthesized a series of thiazolidone and acylthiourea derivatives which are not reported in the literature by introducting 1,2,3-triazole-based, 1,3,4–thiadiazole and dibenzo into acetyl-hydroxy acyl thiazolidoneand thiourea derivatives through the promotion of ultrasonic radiation.

Synthesis of Coumarin-thiazolidinediones;

According to the latest information from the 41~(th) EASD Annual Meeting in 2005,we summarize some noval therapeutic drugs for diabetes,such as non-thiazolidinedione insulin sensitizer incretins,DPP-IV inhibitors,new insulin analogue.

AIM To build a model of two series of PPARγ agonists thiazolidinedione and aryketo-acid derivatives using 3D-QSAR method, and to reveal the structural features affecting the binding activity to PPARγ, which relates to antihyperglycemic and antihyperlipidemic activity and has a potential application to the treatment of type II diabetes.

Fosthiazate was synthesized by condensing 2-thiazolidinone with O,O'-diethylthio- phosphonochloride,and then alkylating the resulting O,O'- diethyl-2-oxo-1,3-thiazolidine-3-thiophosphate with dimethylamine, followedby direct alkylation of the ammonium salt with 2-bromobutane.

Fosthiazate was synthesized by reacting phosphorus trichloride with S-sec-butyl disulfide and then condensing with 2-thiazolidinone.

Its yield of 2-thiazolidinone came up to 82%.

2-Thiazolidinone was synthesized by the exchange reaction between the oxygen of chloroethanol and sulphur atom of 2-thiazolidinethione.

Thiazolidone is synthesized by 2-thiazolidinethione and hydrogen peroxide.

3-Substituted-2-acylimino-4-thiazolidones were synthesized by reaction of N-substituted-N'-benzoyl (or acetyl) ureas with haloacetic acid or ethyl α-bromoacetate and its 5-acetic acid compounds were obtained by reaction of N-aryl-N'-benzoyl ureas with maleic anhydride.

Research Advances of Thiazolidinediones;

The clinical observer on diabetes with thiazolidinediones and insulin;

Peroxisome proliferator-activated receptor-γ agonists or thiazolidinediones(TZD)are a class of agents for the treatment of type 2 diabetes mellitus that act through improvement of insulin sensitivity.