The development of research on nonthiazolidinedione insulin sensitizier is reviewed, including structure activity relationship, mechanism and synthetic methods.

Synthesis of Coumarin-thiazolidinediones;

According to the latest information from the 41~(th) EASD Annual Meeting in 2005,we summarize some noval therapeutic drugs for diabetes,such as non-thiazolidinedione insulin sensitizer incretins,DPP-IV inhibitors,new insulin analogue.

AIM To build a model of two series of PPARγ agonists thiazolidinedione and aryketo-acid derivatives using 3D-QSAR method, and to reveal the structural features affecting the binding activity to PPARγ, which relates to antihyperglycemic and antihyperlipidemic activity and has a potential application to the treatment of type II diabetes.

Research Advances of Thiazolidinediones;

The clinical observer on diabetes with thiazolidinediones and insulin;

Peroxisome proliferator-activated receptor-γ agonists or thiazolidinediones(TZD)are a class of agents for the treatment of type 2 diabetes mellitus that act through improvement of insulin sensitivity.

Direct Protective Effect of Thiazolidinediones on Diabetic Nephropathy;

Therapeutic effect and mechanism of Thiazolidinediones in Nonalcoholic Fatty Liver Disease;

Advancement in the adverse effects of thiazolidinediones;