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1)  mdr1
多药耐药基因-1
1.
Regulation of Y-box protein 1 on the induced expression of mdr1 gene in human leukemia cell line K562;
Y-盒结合蛋白1对白血病K562细胞多药耐药基因-1表达的调控
2)  MDR1
多药耐药基因1
1.
CYP3A5 and MDR1 gene polymorphisms is associated with pharmacokinetic variation of tacrolimus in renal transplant patients;
细胞色素P450 3A5和多药耐药基因1基因多态性在肾移植患者他克莫司血药浓度监测中的应用
2.
Objective To investigate the therapeutic efficacy and the possible action mechanisms of the recombinant adenovirus vector carrying antisense multidrug resistance gene 1(mdr1)targeting the reverse of α-fetoprotein(AFP+)positive MDR of HepG2R cells.
目的探讨携带多药耐药基因1(multidrug resistance gene1,mdr1)反义RNA重组腺病毒载体靶向逆转甲胎蛋白阳性(AFP+)的肝癌多药耐药细胞HepG2R的疗效及作用机制。
3.
Results The influences of independent variables on dependent variables in order of size were MDR1 3435(1)>MDR1 1236(1)>CYP3A5(2)>LDL>DBIL>Age>TC>HDL>L.
结果9个自变量对因变量的影响从大到小依次为多药耐药基因1(MDR1)3435(1)、MDR11236(1)、细胞色素酶P450-3A5(CYP3A5)(2)、低密度脂蛋白胆固醇(LDL)、直接胆红素(DBIL)、年龄、总胆固醇(CHOL)、高密度脂蛋白胆固醇(HDL)、淋巴细胞(L);对方程内各自变量单独检验,CYP3A5(2)、MDR1 3435(1)、MDR1 1236(1)、DBIL、年龄、LDL、HDL对因变量有显著影响。
3)  multidrug resistance 1 gene
多药耐药基因1
1.
Objective To explore the relationship between multidrug resistance 1 gene(mdr1) expression of the gastric cancer and its biological behavior.
目的了解胃癌多药耐药基因1(mdr1)的表达及其与生物学行为的关系。
2.
Objective To investigate whether the polymorphism of multidrug resistance 1 gene( MDR1) in the donors and liver transplantation recipients was correlated with interindividual variation in tacrolimus dose requirement and concentration-to-dose ratio.
目的探讨普乐可复(Tacrolimus,FK506)服用剂量和血药浓度的个体差异与供受体多药耐药基因1(multidrug resistancegene1,MDR1)多态性的关系。
4)  mdr1
多药耐药1基因
1.
The clinical studies of expressions of Fas, P-gp and mdr1 and their correlations in acute leukemia and MDR;
Fas,P-糖蛋白和多药耐药1基因在急性白血病的表达及相关性的临床研究
5)  Multidrug resistance gene 1
多药耐药基因1
1.
Effects of iron-deprivation on the activation of NFκB and the expression of multidrug resistance gene 1 of K562 cells induced by daunorubicin;
铁剥夺对柔红霉素诱导K562细胞多药耐药基因1表达及NFκB活化的影响
2.
Many factors affect the platinum-based chemotherapeutic effect including multidrug resistance gene 1(MDR1) and Excision Repair Cross-Complementation group 1.
导致铂类耐药的原因很多,其中包含多药耐药基因1(MDR1)和切除修复交叉互补基1(ERCC1),其多态性对铂类化疗疗效产生重要影响,并有可能成为预测化疗疗效的因子来指导临床个体化化疗。
3.
Objective To study the relativity of multidrug resistance gene 1(MDR1) gene expression and acquired tolerance to arsenic in human hepatocyte cell line(L-02).
目的观察多药耐药基因1(MDR1)在耐砷的人肝细胞(L-02)中的表达情况,探讨其与L-02耐砷性的关系。
6)  Multi-drug resistance gene 1
多药耐药基因1
1.
Research from home and aboard indicated that CNI\'s differences between individuals had close relationships with cytochrome P3A4 (CYP3A4), cytochrome P3A5 (CYP3A5) and Multi-drug resistance gene 1 (MDR1), the dosage of CNI for the same concentration decreased as follows: mutant homozygote, heterozygote and wild-type homozygote.
国内外学者做了大量研究,认为与细胞色素酶P450-3A4(CYP3A4)、细胞色素酶P450-3A5(CYP3A5)和多药耐药基因1(MDR1)基因多态性关系密切,CNI所需剂量突变型纯合子<杂合子<野生型纯合子,其中MDR1通过编码药物转运体P-糖蛋白(P-gp)发挥作用,而P-gp又与细胞色素酶P450-3A(CYP3A)具有协同和相互调节作用。
补充资料:安眠药、镇静药


安眠药、镇静药
HyPnoties,Sedatives

an而anyao、Zhenjingyao安眠药、镇静药Hypnotics,SedativeS蔡月刚上海医药工业研究院L概述··············……2.主要的安眠、镇静药2.1.醇类·········.··..……2.2.环状酞胺类·····……2.3.酸脉类···········……2.4.氨基甲酸醋类·”一2.5.苯二氮草类····……2.6.吩唯嗦类·······································……312.7.乙醇胺类·······································……312.8.二苯甲烷类······················,····……,··……312.9.叱咯酮类·······································……312.10.巴比妥类·······································……31参考文献················································……咒墓本参考文献··········································……33q八成J gJ广n占亡户nt了0‘2,﹄Q乙2,︺21.概述 安眠药又称催眠药,是一类对中枢神经系统产生抑制作用的药物,在应用适当剂量时,这种抑制作用能导致睡眠(见神经调节荆)。在较小剂量时可使紧张、焦虑和兴奋不安的患者安静下来,有思睡状态,但又不致入睡,这时就称为镇静药。大剂量的安眠药还可产生麻醉。实际上安眠药和镇静药并无明显的界限,而只有量的差别。有些类别的安眠药如使用特大剂量时还可引起昏迷和可能死亡。 失眠是一种不能得到良好睡眠的生理现象,表现为入睡困难、早醒、夜不成寐,即使暂时入睡,但醒后常感头晕脑胀、腰酸背痛,并无正常睡眠醒后的清新之感等等,总之,失眠患者常不能从睡眠中完全消除疲劳。失眠常与下列原因有关;如焦虑、心理障碍、精神上的打击、噪声(见噪声)和工作过度等等。长期失眠可造成中枢神经细胞功能失调,适当应用安眠药是必要的。 理想的安眠药应能使病人安然入睡,而在醒后不遗留任何不适感,并有正常工作的能力。一般患有失眠症的人,服用安眠药后即能获得类似生理性的睡眠,但多数醒后有精神萎靡不振等不良反应。如由于某些躯体疾病,如关节炎、神经痛和心绞痛等引起的失眠,则需首先进行病因性治疗口长期应用安眠药可产生依赖性和成瘾性。 目前对于睡眠发生的机理尚不清楚,但经过多年的努力,已经深入了一步。
说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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