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1)  α-secretase
α-分泌酶
1.
Experimental study on activity ofα-secretase in PS1 mutational transfected cells;
PS1基因突变转染细胞中α-分泌酶活性的实验研究
2.
An experimental study of the effect on α-secretase of rat hippocampal neurons after chronic hypoxic and hypoglycemic culture
慢性低氧低糖培养影响新生大鼠海马神经元α-分泌酶的实验研究
2)  α-secretase
α分泌酶
1.
Effects of 17β-estradiol on α-secretase activity in rat cortical neurons
雌二醇对大鼠皮质原代神经元α分泌酶活性的影响
2.
Alternatively, APP can also be sequential processed by α-secretaseand γ-secretase, which not only preclude the formation of Aβ, but also generate a l.
APP也可在α分泌酶和γ分泌酶的序列作用下水解,既避免了完整Aβ分子的产生,又产生了对细胞有益的胞外片段(sAPPα),因此这条代谢途径已成为研究AD治疗的靶点。
3)  β-secretase
β-分泌酶
1.
β-secretase Interracts with Divalent Cation Tolerant Protein CUTA;
β-分泌酶与二价阳离子耐受蛋白CUTA存在相互作用
2.
The effect of TO901317 on the expression of β-secretase and β-amyloid peptide in hippocampal neuron;
TO901317对海马神经元β-分泌酶表达及β-淀粉样肽生成的影响
3.
Cerebral ischemia injury-induced β-amyloid formation in astrocytes associated with increases of β-secretase in rat brain;
大鼠缺血性脑损伤致星形神经胶质细胞内β-淀粉样蛋白聚集与β-分泌酶增加相关
4)  γ-secretase
γ分泌酶
1.
Assembly of γ-secretase for production of β-amyloid;
催化淀粉样蛋白产生的γ分泌酶的组装
2.
Integral membrane protein presenilin 1(PS1) represents the catalytic component of γ-secretase, and is the crucial protease in the production of β-amyloid (Aβ).
膜蛋白presenilin1(PS1)是γ分泌酶的催化组分,是催化产生β淀粉样蛋白(β-amyloid,Aβ)的关键蛋白酶,因此也是治疗阿尔茨海默病(Alzheimer’s disease,AD)的主要靶点。
3.
Objective Previous studies have revealed that γ-secretase is involved in the pathogenesis of Alzheimer\'s disease.
处理超表达组(T)和对照组(C)细胞,并收集纯化过程中含γ分泌酶复合物的样本,用Western blotting检测γ分泌酶复合物重要组分Nicastrin(NCT)、Presenilin-1(PS-1)以及TMP21的蛋白表达量。
5)  β-secretase
β分泌酶
1.
A screen assay of β-secretase inhibitors in vitro;
β分泌酶抑制剂体外筛选模型的构建与验证
2.
Construction and identification of RNA interfering vector targeting β-secretase;
靶向β分泌酶RNA干扰质粒的构建与鉴定
3.
New development of β-secretase;
酶解淀粉样前体蛋白的β分泌酶研究进展
6)  γ-secretase
γ-分泌酶
1.
Applying Gal4/VP16-UAS and Dual-Luciferase reporter gene system to detecting the activity of γ-secretase;
利用Gal4/VP16-UAS和双荧光素酶报告基因系统检测γ-分泌酶活性
2.
Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;
γ-分泌酶组分基因APH-1A和PEN-2的转录调控
3.
Aβ is derived from β-amyloid precursor protein (APP) through sequential proteolytic cleavages by β-secretase (BACE1) and γ-secretase.
Aβ是由淀粉样前体蛋白(amyloid precursor protein,APP)经β-分泌酶(BACE)和γ-分泌酶水解产生的,因此BACE1在AD的形成过程中发挥重要作用。
补充资料:α,α,α,α',α',α'-六氯对二甲苯
分子式:C8H4Cl6
分子量:312.84
CAS号:68-36-0

性质:白色针状或粉末状结晶。熔点108-110℃。溶于二甲苯、石油醚、乙醇、植物油,不溶于水。无味,有特殊臭味,遇光、碱会缓慢分解而呈酸性。

制备方法:以混二甲苯为原料,先用98%硫酸磺化,使间二甲苯生成间二甲苯磺酸盐。从磺化反应物中分离出含邻、对二甲苯的油层,水洗、干燥,减压蒸馏出邻、对二甲苯。间二甲苯磺酸盐经水解可得副产品间二甲苯。由邻、对二甲苯经氯化即得1,4-双(三氯甲基)苯:在反应锅中投入邻、对二甲苯,再加入过氧化苯甲酰和三乙醇胺。加热到70℃后,在光照射下导入氯气,于70-80℃反应6h,再升温至100-120℃继续反应,至反应液相对密度达到1.560-1.580(65℃),即为反应终点,停止通氯,减压脱除余氯。降温至5℃,过滤,洗涤得粗品,重结晶,活性炭脱色得成品。

用途:抗血吸虫病药物。对肝吸虫病、阿米巴原虫病、疟疾以及肠道线虫有一定疗效。但对神经系统的不良反应较多见,且延迟反应持续较久。

说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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