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1)  hepatocytic stem-like cell
干细胞样肝原始细胞
1.
Objective: To observe the differentiation of mice hepatocytic stem-like cells in vitro.
目的:探讨干细胞样肝原始细胞集落体外分化的潜能。
2)  liver epithelial progenitor cell
肝原始细胞
1.
BACKGROUND AND AIM:To study the differentiation of mouse liver epithelial progenitor cells(LEPCs) to cholangiocytes induced by hairy and enhancer of split 1(Hes1)gene in vitro.
1-Hes1,将2种表达载体分别转染肝原始细胞系(LEPCs),应用RT_PCR和Real-timePCR技术检测胆管细胞分子标志物CK19、GGT,胆管上皮细胞相关转录因子HNF6、HNF1β,肝细胞分子标志物GS、BGP和肝卵圆细胞的分子标志物Thy-1的表达,并在荧光显微镜下观察EGFP标记的LEPCs细胞系荧光强度的变化。
3)  liver progenitor cells
肝原始细胞系
4)  stem like liver cancer cells
干细胞样肝癌细胞
5)  Hepatocyte/Hepatocyte-like cells
肝细胞/肝样细胞
6)  hepatocyte-like cells
肝样细胞
1.
Hepatocyte growth factor and fibroblast growth factor-4-induced differentiation of human bone marrow mesenchymal stem cells into hepatocyte-like cells in vitro;
人骨髓间充质干细胞体外分化为肝样细胞的实验研究
2.
Human bone marrow mesenchymal stem cells differentiating into hepatocyte-like cells after being induced by co-culturing with human hepatocyte line L02;
人肝细胞L02诱导MSCs分化为肝样细胞的观察
3.
Objective To explore the possibility of differentiation of mesenchymal stem cells isolated from patients with hepatocirrhosis into hepatocyte-like cells induced by EGF and HGF and to lay basis for transplanted autologous bone marrow MSCs in treatment of liver disease at terminal stage.
结论HGF、EGF均能诱导骨髓MSCs分化为肝样细胞,两者在一定程度上具有联合作用。
补充资料:肝细胞生长因子样蛋白
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CAS号:

性质:又称肝细胞生长因子样蛋白。从血清中分离出来能刺激巨噬细胞对趋化因子发生反应的蛋白质称为巨噬细胞刺激蛋白。它在人血清中的浓度约为70~260ng/ml。半衰期1.0h。无酶类催化活性。MSP由肝脏分泌,在血循环中以单链形式存在。当蛋白水解酶将它在“精-缬”两氨基酸间肽键切开;形成由二硫键连接的α、β两条肽链后,MSP才有生物活性。其生物学活性主要有:(1)促巨噬细胞趋化作用;(2)刺激巨噬细胞吞噬EIgM C3b;(3)抑制巨噬细胞中NO合酶mRNA(信使核糖核酸)的表达等。现已证实RON基因产物是MSP的受体。在小鼠中,MSP的基因在9号染色体上;人的MSP基因在3号染色体上。

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