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1)  clozapine orally disintegrating tablet
氯氮平口腔崩解片
1.
Objective To develop a rapid and sensitive HPLC-MS/MS method for the analysis of clozapine in human plasma,and to study the pharmacokinetics characteristics of clozapine orally disintegrating tablets after a single oral dose of 25 mg in healthy volunteers.
目的建立快速、灵敏的氯氮平人体内血药浓度的液相色谱串联质谱测定法,并对20名健康志愿者口服氯氮平口腔崩解片后在人体内的药动学过程进行研究。
2)  loratadine orally disintegrating tablet
氯雷他定口腔崩解片
1.
Pharmacokinetics of domestic loratadine orally disintegrating tablets in Chinese healthy volunteers;
国产氯雷他定口腔崩解片人体药动学
2.
OBJECTIVE To study the bioequivalence of loratadine orally disintegrating tablets in Chinese healthy volunteers.
目的对国产氯雷他定口腔崩解片和进口普通片进行生物等效性研究。
3)  orally disintegrating tablets
口腔崩解片
1.
Preparation and dissolution of orally disintegrating tablets of huperzine A;
石杉碱甲口腔崩解片的制备及溶出度考察
2.
Preparation and Quality Control of Nimesulide Orally Disintegrating Tablets;
尼美舒利口腔崩解片的制备及质量检查
3.
Trial-manufacturing of the Granisetron Hydrochloride orally disintegrating tablets;
盐酸格拉司琼口腔崩解片的试制
4)  oral disintegrating tablets
口腔崩解片
1.
Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets;
盐酸三氟拉嗪口腔崩解片的处方筛选及体外溶出度
2.
The formula of breviscapine oral disintegrating tablets and its preparation;
灯盏花素口腔崩解片的制剂处方和制备工艺的研究
3.
Preparation and quality control of meloxicam oral disintegrating tablets;
美洛昔康口腔崩解片的制备及质量控制
5)  Orally disintegrating tablet
口腔崩解片
1.
Bioequivalence of ambroxol hydrochloride orally disintegrating tablets in healthy volunteers;
盐酸氨溴索口腔崩解片的人体生物等效性
2.
Disintegration behavior of ibuprofen microcrystal from orally disintegrating tablets;
布洛芬微晶体在口腔崩解片中的应用
3.
Relative bioavailability and bioequivalence of ibuprofen orally disintegrating tablets in healthy volunteers;
布洛芬口腔崩解片的人体相对生物利用度和生物等效性
6)  paracetamol/caffeine orally disintegrating tablets
酚咖口腔崩解片
补充资料:氯氮
分子式:C16H14ClN3O
分子量:299.75
CAS号:58-25-3

性质:淡黄色结晶性粉末。熔点236- 236.5℃,溶于乙醚、氯仿或二氯甲烷,微溶于水。有微臭,味极苦。其盐酸盐,[438-41-5],为白色晶状粉末,熔点213℃,易溶于水。

制备方法:将2-氨基-5-氯-二苯甲酮与盐酸羟胺在乙醇中回流反应10小时,得到2-氨基-5-氯-二苯酮肟,再经环合、扩环而得。粗品用乙醇重结晶,活性炭脱色,即得成品。

用途:本品为弱安定药,具有镇静、抗焦虑、抗惊厥及肌肉松驰作用。主要用于治疗焦虑症,强迫性神经官能症、神经衰弱失眠及高血压等。与其他抗癫痫药合用可抑制癫痫大发作或小发作。长期大量服用可成瘾。

说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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